Classically, mitochondria have largely been believed to influence the development of illness
by modulating cell metabolism and determining the rate of production of high-energy …

Exposure to a variety of toxins and/or infectious agents leads to disease, degeneration and
death, often characterised by circumstances in which cells or tissues do not merely die and …

Background Out of the myriad of complications associated with septic shock, septic-
associated encephalopathy (SAE) carries a significant risk of morbidity and mortality. Blood …

Mitochondria are an essential part of the cellular infrastructure, being the primary site for
high-energy adenosine triphosphate production through oxidative phosphorylation. Clearly …

Sepsis is characterised by a systemic dysregulated inflammatory response and oxidative
stress, often leading to organ failure and death. Development of organ dysfunction …

Background Several low-molecular-weight phenolic acids are present in the blood of septic
patients at high levels. The microbial origin of the most of phenolic acids in the human body …

Recently, the definition of sepsis was concluded to be a life-threatening organ dysfunction
caused by a dysregulated host response to infection. Severe patients always present with …

Mitochondrial dysfunction is increasingly recognized as an accomplice in most of the
common human diseases including cancer, neurodegeneration, diabetes …

Rationale: Mitochondrial damage is an important component of multiple organ failure
syndrome, a highly lethal complication of severe sepsis that lacks specific therapy …

Sepsis and its derivative syndromes are major causes of morbidity and mortality in the
intensive care unit. Recently, lots of studies have shown that the progression of sepsis is …