The role of phytochemicals in the treatment and prevention of dementia

MJR Howes, E Perry - Drugs & aging, 2011 - Springer
Dementia pathologies such as Alzheimer's disease (AD) are reaching epidemic proportions,
yet they are not successfully managed by effective symptomatic treatments. Only five drugs …

Ethnobotanical treatment strategies against Alzheimer's disease

MJ R Howes, PJ Houghton - Current Alzheimer Research, 2012 - ingentaconnect.com
Ethnobotany encompasses the cultural uses of plants by humans, including their uses as
medicines (ethnopharmacology). The reputed medicinal properties of plants have been …

Traditional Chinese medicine for senile dementia

Z Lin, J Gu, J **u, T Mi, J Dong… - … and Alternative Medicine, 2012 - Wiley Online Library
Traditional Chinese Medicine (TCM) has a 3000 years′ history of human use. A literature
survey addressing traditional evidence from human studies was done, with key result that …

Neuroprotective effects of β-asarone against 6-hydroxy dopamine-induced parkinsonism via JNK/Bcl-2/Beclin-1 pathway

S Zhang, XH Gui, LP Huang, MZ Deng, RM Fang… - Molecular …, 2016 - Springer
Abstract β-asarone, a major component of Acorus tatarinowii Schott, has positive effects in
neurodegeneration disease, however, its effect on the Parkinson's disease (PD) remains …

Polygalae radix inhibits toxin-induced neuronal death in the Parkinson's disease models

JG Choi, HG Kim, MC Kim, WM Yang, Y Huh… - Journal of …, 2011 - Elsevier
AIM OF THE STUDY: Polygalae radix, the root of Polygala tenuifolia Willd, has commonly
been used for the treatment of amnesia and anxiety in traditional Korean medicine. The aim …

Acupuncture activates IRE1/XBP1 endoplasmic reticulum stress pathway in Parkinson's disease model rats

Z Wang, M Kou, Q Deng, H Yu, J Mei, J Gao… - Behavioural Brain …, 2024 - Elsevier
Acupuncture has demonstrated its efficacy as a treatment for Parkinson's disease (PD).
Thus, the objective of this study was to investigate the potential mechanisms underlying …

Tenuigenin protects cultured hippocampal neurons against methylglyoxal-induced neurotoxicity

YJ Chen, XB Huang, ZX Li, LL Yin, WQ Chen… - European journal of …, 2010 - Elsevier
Methylglyoxal is a metabolite of glucose. Since serum methylglyoxal level is increased in
diabetic patients, methylglyoxal is implicated in diabetic complications such as cognitive …

Promising therapeutics with natural bioactive compounds for improving learning and memory—a review of randomized trials

H Kumar, SV More, SD Han, JY Choi, DK Choi - Molecules, 2012 - mdpi.com
Cognitive disorders can be associated with brain trauma, neurodegenerative disease or as
a part of physiological aging. Aging in humans is generally associated with deterioration of …

Polygalae radix extract prevents axonal degeneration and memory deficits in a transgenic mouse model of Alzheimer's disease

T Kuboyama, K Hirotsu, T Arai, H Yamasaki… - Frontiers in …, 2017 - frontiersin.org
Memory impairments in Alzheimer's disease (AD) occur due to degenerated axons and
disrupted neural networks. Since only limited recovery is possible after the destruction of …

Neuroprotective effects of tenuigenin in a SH-SY5Y cell model with 6-OHDA-induced injury

Z Liang, F Shi, Y Wang, L Lu, Z Zhang, X Wang… - Neuroscience …, 2011 - Elsevier
Tenuigenin, an active component of Polygala tenuifolia root extracts, has been shown to
provide antioxidative and anti-aging effects in Alzheimer's disease, as well as to promote …