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The emerging landscape of spatial profiling technologies
Improved scale, multiplexing and resolution are establishing spatial nucleic acid and protein
profiling methods as a major pillar for cellular atlas building of complex samples, from …
profiling methods as a major pillar for cellular atlas building of complex samples, from …
Decoding the tumor microenvironment with spatial technologies
LA Walsh, DF Quail - Nature immunology, 2023 - nature.com
Visualization of the cellular heterogeneity and spatial architecture of the tumor
microenvironment (TME) is becoming increasingly important to understand mechanisms of …
microenvironment (TME) is becoming increasingly important to understand mechanisms of …
Virtual formalin-fixed and paraffin-embedded staining of fresh brain tissue via stimulated Raman CycleGAN model
Engineering the multiscale complexity of vascular networks
The survival of vertebrate organisms depends on highly regulated delivery of oxygen and
nutrients through vascular networks that pervade nearly all tissues in the body …
nutrients through vascular networks that pervade nearly all tissues in the body …
CODA: quantitative 3D reconstruction of large tissues at cellular resolution
A central challenge in biology is obtaining high-content, high-resolution information while
analyzing tissue samples at volumes relevant to disease progression. We address this here …
analyzing tissue samples at volumes relevant to disease progression. We address this here …
Hydrogel machines
As polymer networks infiltrated with water, hydrogels constitute the major components of the
human body; and hydrogels have been widely used in applications that closely interact with …
human body; and hydrogels have been widely used in applications that closely interact with …
Memory engrams: Recalling the past and imagining the future
BACKGROUND The idea that memory is stored as enduring changes in the brain dates
back at least to the time of Plato and Aristotle (circa 350 BCE), but its scientific articulation …
back at least to the time of Plato and Aristotle (circa 350 BCE), but its scientific articulation …
Achieving optical transparency in live animals with absorbing molecules
Optical imaging plays a central role in biology and medicine but is hindered by light
scattering in live tissue. We report the counterintuitive observation that strongly absorbing …
scattering in live tissue. We report the counterintuitive observation that strongly absorbing …
Whole-body cellular map** in mouse using standard IgG antibodies
Whole-body imaging techniques play a vital role in exploring the interplay of physiological
systems in maintaining health and driving disease. We introduce wildDISCO, a new …
systems in maintaining health and driving disease. We introduce wildDISCO, a new …