Emerging studies reveal that neurodegenerative disorders, including amyotrophic lateral
sclerosis (ALS) and frontotemporal dementia (FTD), are commonly linked to DNA damage …

Topoisomerase I (TOP1) inhibitors applied in cancer therapy such as topotecan and
irinotecan are derivatives of the natural alkaloid camptothecin (CPT). The mechanism of …

The appropriate execution of DNA double-strand break (DSB) repair is critical for genome
stability and tumor avoidance. 53BP1 and BRCA1 directly influence DSB repair pathway …

Genome damage and defective repair are etiologically linked to neurodegeneration.
However, the specific mechanisms involved remain enigmatic. Here, we identify defects in …

DNA replication is spatially and temporally regulated during S‐phase. DNA replication
timing is established in early‐G1‐phase at a point referred to as timing decision point …

This study establishes the physiological role of Fused in Sarcoma (FUS) in mitochondrial
DNA (mtDNA) repair and highlights its implications to the pathogenesis of FUS-associated …

DNA replication is temporally and spatially organized in all eukaryotes, yet the molecular
control and biological function of the replication-timing program are unclear. Rif1 is required …

Co-expression of chimeric switch receptors (CSRs) specific for PD-L1 improves the
antitumor effects of chimeric antigen receptor (CAR) T cells. However, the effects of trans …

Telomere length homeostasis is essential for genomic stability and unlimited self-renewal of
embryonic stem cells (ESCs). We show that telomere-associated protein Rif1 is required to …

Abstract The SMYD (SET and MYND domain) family of lysine methyltransferases (KMTs)
plays pivotal roles in various cellular processes, including gene expression regulation and …