Since their inception, genome-wide association studies (GWAS) have identified more than a
hundred thousand single nucleotide polymorphism (SNP) loci that are associated with …

Variation in gene expression is an important mechanism underlying susceptibility to
complex disease. The simultaneous genome-wide assay of gene expression and genetic …

Although genome-wide association studies (GWAS) of complex traits have yielded more
reproducible associations than had been discovered using any other approach, the loci …

Although autism spectrum disorders (ASDs) have a substantial genetic basis, most of the
known genetic risk has been traced to rare variants, principally copy number variants …

Recent genomic profiling of childhood acute lymphoblastic leukemia (ALL) identified a high-
risk subtype with an expression signature resembling that of Philadelphia chromosome …

Genetic map** of complex diseases to date depends on variations inside or close to the
genes that perturb their activities. A strong body of evidence suggests that changes in gene …

Alterations of protein folding or Ca2+ levels within the endoplasmic reticulum (ER) result in
the unfolded-protein response (UPR), a process considered as an endogenous inducer of …

Motivation: Genome-wide association studies (GWAS) generate relationships between
hundreds of thousands of single nucleotide polymorphisms (SNPs) and complex …

There is extensive natural variation in human gene expression. As quantitative phenotypes,
expression levels of genes are heritable. Genetic linkage and association map** have …

In the field of pharmacogenetics, we currently have a few markers to guide physicians as to
the best course of therapy for patients. For the most part, these genetic variants are within a …