Cyclin-dependent kinase pathways as targets for cancer treatment
GI Shapiro - Journal of clinical oncology, 2006 - ascopubs.org
Cyclin-dependent kinases (cdks) are critical regulators of cell cycle progression and RNA
transcription. A variety of genetic and epigenetic events cause universal overactivity of the …
transcription. A variety of genetic and epigenetic events cause universal overactivity of the …
Molecular and functional imaging in cancer-targeted therapy: current applications and future directions
JW Bai, SQ Qiu, GJ Zhang - Signal Transduction and Targeted Therapy, 2023 - nature.com
Targeted anticancer drugs block cancer cell growth by interfering with specific signaling
pathways vital to carcinogenesis and tumor growth rather than harming all rapidly dividing …
pathways vital to carcinogenesis and tumor growth rather than harming all rapidly dividing …
The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins
G Lu, RE Middleton, H Sun, MV Naniong, CJ Ott… - Science, 2014 - science.org
Thalidomide-like drugs such as lenalidomide are clinically important treatments for multiple
myeloma and show promise for other B cell malignancies. The biochemical mechanisms …
myeloma and show promise for other B cell malignancies. The biochemical mechanisms …
Visualizing spatiotemporal dynamics of multicellular cell-cycle progression
A Sakaue-Sawano, H Kurokawa, T Morimura, A Hanyu… - Cell, 2008 - cell.com
The cell-cycle transition from G 1 to S phase has been difficult to visualize. We have
harnessed antiphase oscillating proteins that mark cell-cycle transitions in order to develop …
harnessed antiphase oscillating proteins that mark cell-cycle transitions in order to develop …
SCF ubiquitin ligase-targeted therapies
The clinical successes of proteasome inhibitors for the treatment of cancer have highlighted
the therapeutic potential of targeting this protein degradation system. However, proteasome …
the therapeutic potential of targeting this protein degradation system. However, proteasome …
Optical imaging: current applications and future directions
Optical techniques, such as bioluminescence and fluorescence, are emerging as powerful
new modalities for molecular imaging in disease and therapy. Combining innovative …
new modalities for molecular imaging in disease and therapy. Combining innovative …
The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies
To understand the role of human epidermal growth factor receptor (hEGFR) kinase domain
mutations in lung tumorigenesis and response to EGFR-targeted therapies, we generated …
mutations in lung tumorigenesis and response to EGFR-targeted therapies, we generated …
Roscovitine Targets, Protein Kinases and Pyridoxal Kinase*[Boxs]
(R)-Roscovitine (CYC202) is often referred to as a" selective inhibitor of cyclin-dependent
kinases." Besides its use as a biological tool in cell cycle, neuronal functions, and apoptosis …
kinases." Besides its use as a biological tool in cell cycle, neuronal functions, and apoptosis …
Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction
Deregulated Skp2 function promotes cell transformation, and this is consistent with
observations of Skp2 overexpression in many human cancers. However, the mechanisms …
observations of Skp2 overexpression in many human cancers. However, the mechanisms …
The APC/C inhibitor, Emi1, is essential for prevention of rereplication
YJ Machida, A Dutta - Genes & development, 2007 - genesdev.cshlp.org
Emi1 (early mitotic inhibitor) inhibits APC/C (anaphase-promoting complex/cyclosome)
activity during S and G2 phases, and is believed to be required for proper mitotic entry. We …
activity during S and G2 phases, and is believed to be required for proper mitotic entry. We …