Biointerface design for vertical nanoprobes

R Elnathan, MG Barbato, X Guo, A Mariano… - Nature Reviews …, 2022 - nature.com
Biointerfaces mediate safe and efficient cell manipulation, which is essential for biomedical
innovations in advanced therapies and diagnostics. The biointerface established by vertical …

Recent advances in microscale electroporation

SE Choi, H Khoo, SC Hur - Chemical reviews, 2022 - ACS Publications
Electroporation (EP) is a commonly used strategy to increase cell permeability for
intracellular cargo delivery or irreversible cell membrane disruption using electric fields. In …

Engineering Efficient CAR‐T Cells via Electroactive Nanoinjection

AR Shokouhi, Y Chen, HZ Yoh, J Brenker… - Advanced …, 2023 - Wiley Online Library
Chimeric antigen receptor (CAR)‐T cell therapy has emerged as a promising cell‐based
immunotherapy approach for treating blood disorders and cancers, but genetically …

Tutorial: using nanoneedles for intracellular delivery

C Chiappini, Y Chen, S Aslanoglou, A Mariano… - Nature …, 2021 - nature.com
Intracellular delivery of advanced therapeutics, including biologicals and supramolecular
agents, is complex because of the natural biological barriers that have evolved to protect the …

A comprehensive review on intracellular delivery

D Morshedi Rad, M Alsadat Rad… - Advanced …, 2021 - Wiley Online Library
Intracellular delivery is considered an indispensable process for various studies, ranging
from medical applications (cell‐based therapy) to fundamental (genome‐editing) and …

Microfluidic and nanofluidic intracellular delivery

J Hur, AJ Chung - Advanced Science, 2021 - Wiley Online Library
Innate cell function can be artificially engineered and reprogrammed by introducing
biomolecules, such as DNAs, RNAs, plasmid DNAs, proteins, or nanomaterials, into the …

Electroactive nanoinjection platform for intracellular delivery and gene silencing

AR Shokouhi, Y Chen, HZ Yoh, T Murayama… - Journal of …, 2023 - Springer
Background Nanoinjection—the process of intracellular delivery using vertically configured
nanostructures—is a physical route that efficiently negotiates the plasma membrane, with …

Nanoneedle platforms: the many ways to pierce the cell membrane

G He, N Hu, AM Xu, X Li, Y Zhao… - Advanced functional …, 2020 - Wiley Online Library
Establishing techniques to efficiently and nondestructively access the intracellular milieu is
essential for many biomedical and scientific applications, ranging from drug delivery, to …

Emerging roles of 1D vertical nanostructures in orchestrating immune cell functions

Y Chen, J Wang, X Li, N Hu, NH Voelcker… - Advanced …, 2020 - Wiley Online Library
Engineered nano–bio cellular interfaces driven by 1D vertical nanostructures (1D‐VNS) are
set to prompt radical progress in modulating cellular processes at the nanoscale. Here …

[HTML][HTML] Organic microelectrode arrays for bioelectronic applications

Z Lu, A Pavia, A Savva, L Kergoat… - Materials Science and …, 2023 - Elsevier
Microelectrode arrays (MEAs) are devices that gather multiple microscopic electrodes in a
small area and are used to electrically record and/or stimulate the biological activity of cells …