The roles of FHL2 as a mechanotransducer for cellular functions in the mechanical environment

Y Fujimoto, N Nakazawa - Frontiers in Cell and Developmental …, 2024 - frontiersin.org
The cell has multiple mechanisms for sensing and responding to dynamic changes in the
mechanical environment. In the process, intracellular signaling is activated to modulate …

The roles of FHL2 in cancer

J Zhang, Q Zeng, M She - Clinical and Experimental Medicine, 2023 - Springer
LIM domain protein 2, also known as LIM protein FHL2, is a member of the LIM-only family.
Due to its LIM domain protein characteristics, FHL2 is capable of interacting with various …

FHL2 deficiency impairs follicular development and fertility by attenuating EGF/EGFR/YAP signaling in ovarian granulosa cells

C Wang, H Sun, JS Davis, X Wang, L Huo, N Sun… - Cell Death & …, 2023 - nature.com
Female subfertility is an increasing reproductive issue worldwide, which is partially related to
abnormal ovarian follicular development. Granulosa cells (GCs), by providing the necessary …

Integration of single-cell RNA sequencing and bulk RNA sequencing data to establish and validate a prognostic model for patients with lung adenocarcinoma

A Jiang, J Wang, N Liu, X Zheng, Y Li, Y Ma… - Frontiers in …, 2022 - frontiersin.org
Background: Lung adenocarcinoma (LUAD) remains a lethal disease worldwide, with
numerous studies exploring its potential prognostic markers using traditional RNA …

Silencing FHL2 inhibits bleomycin-induced pulmonary fibrosis through the TGF-β1/Smad signaling pathway

M Shi, H Cui, J Shi, Y Mei - Experimental Cell Research, 2023 - Elsevier
Objective This study aimed to investigate the inhibiting effects of FHL2 and Arbutin on cell
fibrosis and their possible mechanisms. Methods The mRNA expression of FHL2 in …

Novel Insight Into the Role of ACSL1 Gene in Milk Production Traits in Buffalo

Y Lin, H Sun, A Shaukat, T Deng, H Abdel-Shafy… - Frontiers in …, 2022 - frontiersin.org
Understanding the genetic mechanisms underlying milk production traits contribute to
improving the production potential of dairy animals. Long-chain acyl-CoA synthetase 1 …

Comparative genomic analysis of the Thiolase family and functional characterization of the acetyl-coenzyme a Acyltransferase-1 gene for Milk biosynthesis and …

T Deng, J Wu, H Abdel-Shafy, X Wang… - Journal of Agricultural …, 2023 - ACS Publications
Cattle and buffalo served as the first and second largest dairy animals, respectively,
providing 96% milk products worldwide. Understanding the mechanisms underlying milk …

[HTML][HTML] How (epi) genetic regulation of the LIM-domain protein FHL2 impacts multifactorial disease

JJ Habibe, MP Clemente-Olivo, CJ de Vries - Cells, 2021 - mdpi.com
Susceptibility to complex pathological conditions such as obesity, type 2 diabetes and
cardiovascular disease is highly variable among individuals and arises from specific …

HBXIP knockdown inhibits FHL2 to promote cycle arrest and suppress cervical cancer cell proliferation, invasion and migration

X Gao, L Yang - Oncology Letters, 2023 - spandidos-publications.com
Hepatitis B X-interacting protein (HBXIP) and four and a half LIM domain 2 (FHL2) have
been reported to serve as independent biomarkers for cervical cancer. The present study …

High level of FHL2 exacerbates the outcome of non‐small cell lung cancer (NSCLC) patients and the malignant phenotype in NSCLC cells

N Li, L Xu, J Zhang, Y Liu - International Journal of …, 2022 - Wiley Online Library
Non‐small cell lung cancer (NSCLC) is a malignant tumour with high mortality. FHL2 has
been identified as a biomarker of lung cancer. This research explored the effects of FHL2 …