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The roles of FHL2 as a mechanotransducer for cellular functions in the mechanical environment
Y Fujimoto, N Nakazawa - Frontiers in Cell and Developmental …, 2024 - frontiersin.org
The cell has multiple mechanisms for sensing and responding to dynamic changes in the
mechanical environment. In the process, intracellular signaling is activated to modulate …
mechanical environment. In the process, intracellular signaling is activated to modulate …
The roles of FHL2 in cancer
J Zhang, Q Zeng, M She - Clinical and Experimental Medicine, 2023 - Springer
LIM domain protein 2, also known as LIM protein FHL2, is a member of the LIM-only family.
Due to its LIM domain protein characteristics, FHL2 is capable of interacting with various …
Due to its LIM domain protein characteristics, FHL2 is capable of interacting with various …
FHL2 deficiency impairs follicular development and fertility by attenuating EGF/EGFR/YAP signaling in ovarian granulosa cells
C Wang, H Sun, JS Davis, X Wang, L Huo, N Sun… - Cell Death & …, 2023 - nature.com
Female subfertility is an increasing reproductive issue worldwide, which is partially related to
abnormal ovarian follicular development. Granulosa cells (GCs), by providing the necessary …
abnormal ovarian follicular development. Granulosa cells (GCs), by providing the necessary …
Integration of single-cell RNA sequencing and bulk RNA sequencing data to establish and validate a prognostic model for patients with lung adenocarcinoma
A Jiang, J Wang, N Liu, X Zheng, Y Li, Y Ma… - Frontiers in …, 2022 - frontiersin.org
Background: Lung adenocarcinoma (LUAD) remains a lethal disease worldwide, with
numerous studies exploring its potential prognostic markers using traditional RNA …
numerous studies exploring its potential prognostic markers using traditional RNA …
Silencing FHL2 inhibits bleomycin-induced pulmonary fibrosis through the TGF-β1/Smad signaling pathway
M Shi, H Cui, J Shi, Y Mei - Experimental Cell Research, 2023 - Elsevier
Objective This study aimed to investigate the inhibiting effects of FHL2 and Arbutin on cell
fibrosis and their possible mechanisms. Methods The mRNA expression of FHL2 in …
fibrosis and their possible mechanisms. Methods The mRNA expression of FHL2 in …
Novel Insight Into the Role of ACSL1 Gene in Milk Production Traits in Buffalo
Understanding the genetic mechanisms underlying milk production traits contribute to
improving the production potential of dairy animals. Long-chain acyl-CoA synthetase 1 …
improving the production potential of dairy animals. Long-chain acyl-CoA synthetase 1 …
Comparative genomic analysis of the Thiolase family and functional characterization of the acetyl-coenzyme a Acyltransferase-1 gene for Milk biosynthesis and …
Cattle and buffalo served as the first and second largest dairy animals, respectively,
providing 96% milk products worldwide. Understanding the mechanisms underlying milk …
providing 96% milk products worldwide. Understanding the mechanisms underlying milk …
[HTML][HTML] How (epi) genetic regulation of the LIM-domain protein FHL2 impacts multifactorial disease
JJ Habibe, MP Clemente-Olivo, CJ de Vries - Cells, 2021 - mdpi.com
Susceptibility to complex pathological conditions such as obesity, type 2 diabetes and
cardiovascular disease is highly variable among individuals and arises from specific …
cardiovascular disease is highly variable among individuals and arises from specific …
HBXIP knockdown inhibits FHL2 to promote cycle arrest and suppress cervical cancer cell proliferation, invasion and migration
X Gao, L Yang - Oncology Letters, 2023 - spandidos-publications.com
Hepatitis B X-interacting protein (HBXIP) and four and a half LIM domain 2 (FHL2) have
been reported to serve as independent biomarkers for cervical cancer. The present study …
been reported to serve as independent biomarkers for cervical cancer. The present study …
High level of FHL2 exacerbates the outcome of non‐small cell lung cancer (NSCLC) patients and the malignant phenotype in NSCLC cells
N Li, L Xu, J Zhang, Y Liu - International Journal of …, 2022 - Wiley Online Library
Non‐small cell lung cancer (NSCLC) is a malignant tumour with high mortality. FHL2 has
been identified as a biomarker of lung cancer. This research explored the effects of FHL2 …
been identified as a biomarker of lung cancer. This research explored the effects of FHL2 …