Microtubules are dynamic filamentous cytoskeletal proteins composed of tubulin and are an
important therapeutic target in tumour cells. Agents that bind to microtubules have been part …

Microtubules (composed of α-and β-tubulin heterodimers) play a pivotal role in mitosis and
cell division, and are regarded as an excellent target for chemotherapeutic agents to treat …

A number of microtubule (MT)-stabilizing agents (MSAs) have demonstrated or predicted
potential as anticancer agents, but a detailed structural basis for their mechanism of action is …

Natural as well as synthetic coumarins have recently drawn much attention due to its broad
pharmacological activities. Many coumarins and their derivatives exert anti-coagulant, anti …

Colchicine, the main alkaloid of Colchicum autumnale, is one of the most famous natural
molecules. Although colchicine belongs to the oldest drugs (in use since 1500 BC), its …

The microtubule (MT) associated protein tau, which is highly expressed in the axons of
neurons, is an endogenous MT-stabilizing agent that plays an important role in axonal …

Drugs that affect microtubule dynamics, including the taxanes and vinca alkaloids, have
been a mainstay in the treatment of leukemias and solid tumors for decades. New, more …

A pair of extensively modified microtubules form the central apparatus (CA) of the axoneme
of most motile cilia, where they regulate ciliary motility. The external surfaces of both CA …

Covering: up to June 2006This review article provides an overview on the current state of
research in the area of microtubule-stabilizing agents from natural sources, with a primary …

In living cells, microtubules (MTs) play pleiotropic roles, which require very different
mechanical properties. Unlike the dynamic MTs found in the cytoplasm of metazoan cells …