Sex hormones determine immune response

V Taneja - Frontiers in immunology, 2018 - frontiersin.org
Females and males differ in the energy consumption and nutritional requirements which are
based on the interactions between environmental factors and sex hormones (1). The studies …

Neuronal regulation of immunity: why, how and where?

M Schiller, TL Ben-Shaanan, A Rolls - Nature Reviews Immunology, 2021 - nature.com
Neuroimmunology is one of the fastest-growing fields in the life sciences, and for good
reason; it fills the gap between two principal systems of the organism, the nervous system …

Chronic inflammatory systemic diseases: An evolutionary trade-off between acutely beneficial but chronically harmful programs

RH Straub, C Schradin - Evolution, medicine, and public health, 2016 - academic.oup.com
It has been recognized that during chronic inflammatory systemic diseases (CIDs)
maladaptations of the immune, nervous, endocrine and reproductive system occur …

Why women have more autoimmune diseases than men: An evolutionary perspective

VL Kronzer, SL Bridges Jr… - Evolutionary …, 2021 - Wiley Online Library
Women have up to a fourfold increase in risk for autoimmune disease compared to men.
Many explanations have been proposed, including sex hormones, the X chromosome …

Breaking tolerance to thyroid antigens: changing concepts in thyroid autoimmunity

SM McLachlan, B Rapoport - Endocrine reviews, 2014 - academic.oup.com
Thyroid autoimmunity involves loss of tolerance to thyroid proteins in genetically susceptible
individuals in association with environmental factors. In central tolerance, intrathymic …

Targeting brain-peripheral immune responses for secondary brain injury after ischemic and hemorrhagic stroke

M Duan, Y Xu, Y Li, H Feng, Y Chen - Journal of Neuroinflammation, 2024 - Springer
The notion that the central nervous system is an immunologically immune-exempt organ has
changed over the past two decades, with increasing evidence of strong links and …

The gut microbiome in autoimmunity: sex matters

A Gomez, D Luckey, V Taneja - Clinical immunology, 2015 - Elsevier
Autoimmune diseases like rheumatoid arthritis are multifactorial in nature, requiring both
genetic and environmental factors for onset. Increased predisposition of females to a wide …

MHC class II polymorphisms, autoreactive T-cells, and autoimmunity

S Tsai, P Santamaria - Frontiers in immunology, 2013 - frontiersin.org
Major histocompatibility complex (MHC) genes, also known as human leukocyte antigen
genes (HLA) in humans, are the prevailing contributors of genetic susceptibility to …

[HTML][HTML] Epstein–Barr virus-acquired immunodeficiency in myalgic encephalomyelitis—Is it present in long COVID?

M Ruiz-Pablos, B Paiva, A Zabaleta - Journal of translational medicine, 2023 - Springer
Both myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS) and long COVID
(LC) are characterized by similar immunological alterations, persistence of chronic viral …

Infections and risk of celiac disease in childhood: a prospective nationwide cohort study

K Mårild, CR Kahrs, G Tapia, LC Stene… - Official journal of the …, 2015 - journals.lww.com
Objectives: Studies on early life infections and risk of later celiac disease (CD) are
inconsistent but have mostly been limited to retrospective designs, inpatient data, or …