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Vascular smooth muscle cells in atherosclerosis: time for a re-assessment
Vascular smooth muscle cells (VSMCs) are key participants in both early and late-stage
atherosclerosis. VSMCs invade the early atherosclerotic lesion from the media, expanding …
atherosclerosis. VSMCs invade the early atherosclerotic lesion from the media, expanding …
Probing the links: long non-coding RNAs and NF-κB signalling in atherosclerosis
Atherosclerosis is a chronic inflammatory disease that involves the accumulation of lipids
and immune cells in the arterial wall. NF-kB signaling is a key regulator of inflammation and …
and immune cells in the arterial wall. NF-kB signaling is a key regulator of inflammation and …
Single-cell genomics reveals a novel cell state during smooth muscle cell phenotypic switching and potential therapeutic targets for atherosclerosis in mouse and …
Background: Smooth muscle cells (SMCs) play significant roles in atherosclerosis via
phenotypic switching, a pathological process in which SMC dedifferentiation, migration, and …
phenotypic switching, a pathological process in which SMC dedifferentiation, migration, and …
Mitochondrial C5aR1 activity in macrophages controls IL-1β production underlying sterile inflammation
While serum-circulating complement destroys invading pathogens, intracellularly active
complement, termed the “complosome,” functions as a vital orchestrator of cell-metabolic …
complement, termed the “complosome,” functions as a vital orchestrator of cell-metabolic …
Circular RNA CircMAP3K5 acts as a MicroRNA-22-3p sponge to promote resolution of intimal hyperplasia via TET2-mediated smooth muscle cell differentiation
Z Zeng, L ** reveals site-specific pathways underlying human atherosclerotic plaque rupture
Background Atherosclerotic plaque ruptures, triggered by blood flow–associated
biomechanical forces, cause most myocardial infarctions and strokes. Objectives This study …
biomechanical forces, cause most myocardial infarctions and strokes. Objectives This study …
CARMN Loss Regulates Smooth Muscle Cells and Accelerates Atherosclerosis in Mice
Rationale: In the microenvironment of atherosclerotic lesions, vascular smooth muscle cells
(vSMCs) switch to a dedifferentiated state but the underlying molecular mechanisms driving …
(vSMCs) switch to a dedifferentiated state but the underlying molecular mechanisms driving …
[HTML][HTML] Integrative single-cell meta-analysis reveals disease-relevant vascular cell states and markers in human atherosclerosis
Coronary artery disease (CAD) is characterized by atherosclerotic plaque formation in the
arterial wall. CAD progression involves complex interactions and phenotypic plasticity …
arterial wall. CAD progression involves complex interactions and phenotypic plasticity …