[HTML][HTML] Acyl-CoA: diacylglycerol acyltransferase: Properties, physiological roles, metabolic engineering and intentional control
Acyl-CoA: diacylglycerol acyltransferase (DGAT, EC 2.3. 1.20) catalyzes the last reaction in
the acyl-CoA-dependent biosynthesis of triacylglycerol (TAG). DGAT activity resides mainly …
the acyl-CoA-dependent biosynthesis of triacylglycerol (TAG). DGAT activity resides mainly …
DAG tales: the multiple faces of diacylglycerol—stereochemistry, metabolism, and signaling
TO Eichmann, A Lass - Cellular and Molecular Life Sciences, 2015 - Springer
The neutral lipids diacylglycerols (DAGs) are involved in a plethora of metabolic pathways.
They function as components of cellular membranes, as building blocks for glycero …
They function as components of cellular membranes, as building blocks for glycero …
[HTML][HTML] The triglyceride synthesis enzymes DGAT1 and DGAT2 have distinct and overlap** functions in adipocytes
Mammals store metabolic energy as triacylglycerols (TGs) in adipose tissue. TG synthesis is
catalyzed by the evolutionarily unrelated acyl-CoA: diacylglycerol acyltransferase (DGAT) …
catalyzed by the evolutionarily unrelated acyl-CoA: diacylglycerol acyltransferase (DGAT) …
Role of DGAT enzymes in triacylglycerol metabolism
B Bhatt-Wessel, TW Jordan, JH Miller, L Peng - Archives of biochemistry …, 2018 - Elsevier
The esterification of a fatty acyl moiety to diacylglycerol to form triacylglycerol (TAG) is
catalysed by two diacylglycerol O-acyltransferases (DGATs) encoded by genes belonging to …
catalysed by two diacylglycerol O-acyltransferases (DGATs) encoded by genes belonging to …
Acyl-CoA: diacylglycerol acyltransferase: molecular biology, biochemistry and biotechnology
Triacylglycerol (TG) is a storage lipid which serves as an energy reservoir and a source of
signalling molecules and substrates for membrane biogenesis. TG is essential for many …
signalling molecules and substrates for membrane biogenesis. TG is essential for many …
A negative-solvatochromic fluorescent probe for visualizing intracellular distributions of fatty acid metabolites
K Kajiwara, H Osaki, S Greßies, K Kuwata… - Nature …, 2022 - nature.com
Metabolic distribution of fatty acid to organelles is an essential biological process for energy
homeostasis as well as for the maintenance of membrane integrity, and the metabolic …
homeostasis as well as for the maintenance of membrane integrity, and the metabolic …
Structure and mechanism of human diacylglycerol O-acyltransferase 1
Abstract Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is
required for dietary fat absorption and fat storage in humans. DGAT1 belongs to the …
required for dietary fat absorption and fat storage in humans. DGAT1 belongs to the …
The life cycle of lipid droplets
HF Hashemi, JM Goodman - Current opinion in cell biology, 2015 - Elsevier
Proteomic studies have revealed many potential functions of cytoplasmic lipid droplets, and
recent activity has confirmed that these bona fide organelles are central not only for lipid …
recent activity has confirmed that these bona fide organelles are central not only for lipid …
How lipid droplets “TAG” along: Glycerolipid synthetic enzymes and lipid storage
Triacylglycerols (TAG) serve as the predominant form of energy storage in mammalian cells,
and TAG synthesis influences conditions such as obesity, fatty liver, and insulin resistance …
and TAG synthesis influences conditions such as obesity, fatty liver, and insulin resistance …
Intestinal triacylglycerol synthesis in fat absorption and systemic energy metabolism
CLE Yen, DW Nelson, MI Yen - Journal of lipid research, 2015 - ASBMB
The intestine plays a prominent role in the biosynthesis of triacylglycerol (triglyceride; TAG).
Digested dietary TAG is repackaged in the intestine to form the hydrophobic core of …
Digested dietary TAG is repackaged in the intestine to form the hydrophobic core of …