IL-1 and autoinflammatory disease: biology, pathogenesis and therapeutic targeting
L Broderick, HM Hoffman - Nature Reviews Rheumatology, 2022 - nature.com
Over 20 years ago, it was first proposed that autoinflammation underpins a handful of rare
monogenic disorders characterized by recurrent fever and systemic inflammation. The …
monogenic disorders characterized by recurrent fever and systemic inflammation. The …
Inflammasomes in alveolar bone loss
Y Li, J Ling, Q Jiang - Frontiers in immunology, 2021 - frontiersin.org
Bone remodeling is tightly controlled by osteoclast-mediated bone resorption and osteoblast-
mediated bone formation. Fine tuning of the osteoclast–osteoblast balance results in strict …
mediated bone formation. Fine tuning of the osteoclast–osteoblast balance results in strict …
The role of inflammasomes in kidney disease
T Komada, DA Muruve - Nature Reviews Nephrology, 2019 - nature.com
Inflammasomes are multiprotein innate immune complexes that regulate caspase-
dependent inflammation and cell death. Pattern recognition receptors, such as nucleotide …
dependent inflammation and cell death. Pattern recognition receptors, such as nucleotide …
Role of inflammasomes in the pathogenesis of periodontal disease and therapeutics
JT Marchesan, MS Girnary, K Moss… - Periodontology …, 2020 - Wiley Online Library
Inflammasomes are a group of multimolecular intracellular complexes assembled around
several innate immune proteins. Recognition of a diverse range of microbial, stress and …
several innate immune proteins. Recognition of a diverse range of microbial, stress and …
Caps and NLRP3
LM Booshehri, HM Hoffman - Journal of clinical immunology, 2019 - Springer
Cryopyrin-associated periodic syndrome (CAPS) is a rare inherited autoinflammatory
disorder characterized by systemic, cutaneous, musculoskeletal, and central nervous system …
disorder characterized by systemic, cutaneous, musculoskeletal, and central nervous system …
Horror Autoinflammaticus: The Molecular Pathophysiology of Autoinflammatory Disease
SL Masters, A Simon, I Aksentijevich… - Annual review of …, 2009 - annualreviews.org
The autoinflammatory diseases are characterized by seemingly unprovoked episodes of
inflammation, without high-titer autoantibodies or antigen-specific T cells. The concept was …
inflammation, without high-titer autoantibodies or antigen-specific T cells. The concept was …
A new autoinflammatory and autoimmune syndrome associated with NLRP1 mutations: NAIAD (NLRP1-associated autoinflammation with arthritis and dyskeratosis)
S Grandemange, E Sanchez, P Louis-Plence… - Annals of the …, 2017 - ard.bmj.com
Objectives Inflammasomes are multiprotein complexes that sense pathogens and trigger
biological mechanisms to control infection. Nucleotide-binding oligomerisation domain-like …
biological mechanisms to control infection. Nucleotide-binding oligomerisation domain-like …
The NLRP3 and pyrin inflammasomes: implications in the pathophysiology of autoinflammatory diseases
C de Torre-Minguela, P Mesa del Castillo… - Frontiers in …, 2017 - frontiersin.org
Inflammasomes are multiprotein complexes that critically control different aspects of innate
and adaptive immunity. Among them we could highlight the release of pro-inflammatory …
and adaptive immunity. Among them we could highlight the release of pro-inflammatory …
The inflammasomes and autoinflammatory syndromes
L Broderick, D De Nardo, BS Franklin… - Annual Review of …, 2015 - annualreviews.org
Inflammation, a vital response of the immune system to infection and damage to tissues, can
be initiated by various germline-encoded innate immune-signaling receptors. Among these …
be initiated by various germline-encoded innate immune-signaling receptors. Among these …
Evidence-based provisional clinical classification criteria for autoinflammatory periodic fevers
The objective of this work was to develop and validate a set of clinical criteria for the
classification of patients affected by periodic fevers. Patients with inherited periodic fevers …
classification of patients affected by periodic fevers. Patients with inherited periodic fevers …