Dynamic EMT: a multi‐tool for tumor progression

S Brabletz, H Schuhwerk, T Brabletz… - The EMBO journal, 2021 - embopress.org
The process of epithelial–mesenchymal transition (EMT) is fundamental for embryonic
morphogenesis. Cells undergoing it lose epithelial characteristics and integrity, acquire …

Mechanism of epithelial‐mesenchymal transition in cancer and its regulation by natural compounds

HL Ang, CD Mohan, MK Shanmugam… - Medicinal research …, 2023 - Wiley Online Library
Epithelial‐mesenchymal transition (EMT) is a complex process with a primordial role in
cellular transformation whereby an epithelial cell transforms and acquires a mesenchymal …

Novel therapeutic strategies: Targeting epithelial–mesenchymal transition in colorectal cancer

N Zhang, AS Ng, S Cai, Q Li, L Yang, D Kerr - The lancet oncology, 2021 - thelancet.com
Epithelial–mesenchymal transition (EMT) is a process during which cells lose their epithelial
characteristics, for instance apical–basal cell polarity and cell–cell contact, and gain …

RNA-binding proteins in cancer: old players and new actors

B Pereira, M Billaud, R Almeida - Trends in cancer, 2017 - cell.com
RNA-binding proteins (RBPs) are key players in post-transcriptional events. The
combination of versatility of their RNA-binding domains with structural flexibility enables …

RNA-binding proteins in tumor progression

H Qin, H Ni, Y Liu, Y Yuan, T **, X Li… - Journal of hematology & …, 2020 - Springer
RNA-binding protein (RBP) has a highly dynamic spatiotemporal regulation process and
important biological functions. They are critical to maintain the transcriptome through post …

Tumor microenvironment heterogeneity an important mediator of prostate cancer progression and therapeutic resistance

R Ge, Z Wang, L Cheng - NPJ precision oncology, 2022 - nature.com
Prostate cancer is characterized by a high degree of heterogeneity, which poses a major
challenge to precision therapy and drug development. In this review, we discuss how …

Crosstalk between autophagy and epithelial-mesenchymal transition and its application in cancer therapy

HT Chen, H Liu, MJ Mao, Y Tan, XQ Mo, XJ Meng… - Molecular cancer, 2019 - Springer
Autophagy is a highly conserved catabolic process that mediates degradation of pernicious
or dysfunctional cellular components, such as invasive pathogens, senescent proteins, and …

Nickel (Ni) phytotoxicity and detoxification mechanisms: A review

A Mustafa, U Zulfiqar, MZ Mumtaz, M Radziemska… - Chemosphere, 2023 - Elsevier
Scientists studying the environment, physiology, and biology have been particularly
interested in nickel (Ni) because of its dual effects (essentiality and toxicity) on terrestrial …

Hybrid epithelial/mesenchymal phenotypes promote metastasis and therapy resistance across carcinomas

MK Jolly, JA Somarelli, M Sheth, A Biddle… - Pharmacology & …, 2019 - Elsevier
Cancer metastasis and therapy resistance are the major unsolved clinical challenges, and
account for nearly all cancer-related deaths. Both metastasis and therapy resistance are …

Epithelial plasticity, epithelial-mesenchymal transition, and the TGF-β family

Y Katsuno, R Derynck - Developmental cell, 2021 - cell.com
Epithelial cells repress epithelial characteristics and elaborate mesenchymal characteristics
to migrate to other locations and acquire new properties. Epithelial plasticity responses are …