Over the past three years (2020–2022) more structures of GPCRs have been determined
than in the previous twenty years (2000–2019), primarily of GPCR complexes that are large …

Abstract Purpose of Review This study aims to review the hunger hormones in obesity
management and the impact of oats in regulating these hormones for hunger suppression …

Designer receptors exclusively activated by designer drugs (DREADDs) represent a
powerful chemogenetic technology for the remote control of neuronal activity and cellular …

Trace amine-associated receptor 1 (TAAR1) senses a spectrum of endogenous amine-
containing metabolites (EAMs) to mediate diverse psychological functions and is useful for …

Gastrin releasing peptide receptor (GRPR), a member of the bombesin (BBN) G protein-
coupled receptors, is aberrantly overexpressed in several malignant tumors, including those …

Adhesion G-protein-coupled receptors (aGPCRs) play key roles in a diversity of
physiologies. A hallmark of aGPCR activation is the removal of the inhibitory GAIN domain …

The endothelin ET B receptor is a promiscuous G-protein coupled receptor that is activated
by vasoactive peptide endothelins. ET B signaling induces reactive astrocytes in the brain …

Adhesion G protein-coupled receptors (aGPCRs) are keys of many physiological events and
attractive targets for various diseases. aGPCRs are also known to be capable of self …

Histamine is a biogenic amine that participates in allergic and inflammatory processes by
stimulating histamine receptors. The histamine H4 receptor (H4R) is a potential therapeutic …

Much effort has been invested in the investigation of the structural basis of G protein-coupled
receptors (GPCRs) activation. Inverse agonists, which can inhibit GPCRs with constitutive …