[HTML][HTML] New insights into GPCR coupling and dimerisation from cryo-EM structures
Over the past three years (2020–2022) more structures of GPCRs have been determined
than in the previous twenty years (2000–2019), primarily of GPCR complexes that are large …
than in the previous twenty years (2000–2019), primarily of GPCR complexes that are large …
Impact of oats on appetite hormones and body weight management: a review
Abstract Purpose of Review This study aims to review the hunger hormones in obesity
management and the impact of oats in regulating these hormones for hunger suppression …
management and the impact of oats in regulating these hormones for hunger suppression …
Molecular basis for selective activation of DREADD-based chemogenetics
Designer receptors exclusively activated by designer drugs (DREADDs) represent a
powerful chemogenetic technology for the remote control of neuronal activity and cellular …
powerful chemogenetic technology for the remote control of neuronal activity and cellular …
Structural insights into adhesion GPCR ADGRL3 activation and Gq, Gs, Gi, and G12 coupling
Y Qian, Z Ma, C Liu, X Li, X Zhu, N Wang, Z Xu, R **a… - Molecular Cell, 2022 - cell.com
Adhesion G-protein-coupled receptors (aGPCRs) play key roles in a diversity of
physiologies. A hallmark of aGPCR activation is the removal of the inhibitory GAIN domain …
physiologies. A hallmark of aGPCR activation is the removal of the inhibitory GAIN domain …
Structural and signaling mechanisms of TAAR1 enabled preferential agonist design
P Shang, N Rong, JJ Jiang, J Cheng, MH Zhang… - Cell, 2023 - cell.com
Trace amine-associated receptor 1 (TAAR1) senses a spectrum of endogenous amine-
containing metabolites (EAMs) to mediate diverse psychological functions and is useful for …
containing metabolites (EAMs) to mediate diverse psychological functions and is useful for …
Structural insights into the agonists binding and receptor selectivity of human histamine H4 receptor
Histamine is a biogenic amine that participates in allergic and inflammatory processes by
stimulating histamine receptors. The histamine H4 receptor (H4R) is a potential therapeutic …
stimulating histamine receptors. The histamine H4 receptor (H4R) is a potential therapeutic …
Cryo-EM structure of the endothelin-1-ETB-Gi complex
FK Sano, H Akasaka, W Shihoya, O Nureki - elife, 2023 - elifesciences.org
The endothelin ET B receptor is a promiscuous G-protein coupled receptor that is activated
by vasoactive peptide endothelins. ET B signaling induces reactive astrocytes in the brain …
by vasoactive peptide endothelins. ET B signaling induces reactive astrocytes in the brain …
Structural basis of adhesion GPCR GPR110 activation by stalk peptide and G-proteins coupling
X Zhu, Y Qian, X Li, Z Xu, R **a, N Wang… - Nature …, 2022 - nature.com
Adhesion G protein-coupled receptors (aGPCRs) are keys of many physiological events and
attractive targets for various diseases. aGPCRs are also known to be capable of self …
attractive targets for various diseases. aGPCRs are also known to be capable of self …
Structures of human gastrin-releasing peptide receptors bound to antagonist and agonist for cancer and itch therapy
S Peng, Y Zhan, D Zhang, L Ren… - Proceedings of the …, 2023 - National Acad Sciences
Gastrin releasing peptide receptor (GRPR), a member of the bombesin (BBN) G protein-
coupled receptors, is aberrantly overexpressed in several malignant tumors, including those …
coupled receptors, is aberrantly overexpressed in several malignant tumors, including those …
Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors
Peptide hormones and neuropeptides are complex signaling molecules that predominately
function through G protein-coupled receptors (GPCRs). Two unanswered questions …
function through G protein-coupled receptors (GPCRs). Two unanswered questions …