Sarcomas are complex mesenchymal neoplasms with a poor prognosis. Their clinical
management is highly challenging due to their heterogeneity and insensitivity to current …

Abstract Changes in chromatin structure mediated by ATP-dependent nucleosome
remodelers and histone modifying enzymes are integral to the process of gene regulation …

Accurate measurement of clonal genotypes, mutational processes, and replication states
from individual tumor-cell genomes will facilitate improved understanding of tumor evolution …

The immunosuppressive tumor microenvironment (TME) is a major barrier to
immunotherapy. Within solid tumors, why monocytes preferentially differentiate into …

Synovial sarcoma (SS) is defined by the hallmark SS18-SSX fusion oncoprotein, which
renders BAF complexes aberrant in two manners: gain of SSX to the SS18 subunit and …

Synovial sarcoma tumours contain a characteristic fusion protein, SS18-SSX, which drives
disease development. Targeting oncogenic fusion proteins presents an attractive …

Synovial sarcoma (SS) is a malignant mesenchymal neoplasm with variable epithelial
differentiation, with a propensity to occur in young adults and which can arise at almost any …

Increasingly, human mesenchymal malignancies are being classified by the abnormalities
that drive their pathogenesis. Although many of these aberrations are highly prevalent within …

Synovial sarcoma (SS) is a rare sarcoma driven by a translocation between SS18 and SSX
1, 2, or 4. With approximately 800 to 1,000 cases a year in the United States, it most …

Skeletal muscle contains Pax7-expressing muscle stem or satellite cells, enabling muscle
regeneration throughout most of adult life. Here, we demonstrate that induced inactivation of …