The roles of TGFβ in the tumour microenvironment
The influence of the microenvironment on tumour progression is becoming clearer. In this
Review we address the role of an essential signalling pathway, that of transforming growth …
Review we address the role of an essential signalling pathway, that of transforming growth …
Transforming growth factor-β in stem cells and tissue homeostasis
Abstract TGF-β 1–3 are unique multi-functional growth factors that are only expressed in
mammals, and mainly secreted and stored as a latent complex in the extracellular matrix …
mammals, and mainly secreted and stored as a latent complex in the extracellular matrix …
NOTCH1 mediates a switch between two distinct secretomes during senescence
Senescence, a persistent form of cell-cycle arrest, is often associated with a diverse
secretome, which provides complex functionality for senescent cells within the tissue …
secretome, which provides complex functionality for senescent cells within the tissue …
The effect of matrix stiffness on the differentiation of mesenchymal stem cells in response to TGF-β
Bone marrow mesenchymal stem cells (MSCs) are a valuable cell source for tissue
engineering and regenerative medicine. Transforming growth factor β (TGF-β) can promote …
engineering and regenerative medicine. Transforming growth factor β (TGF-β) can promote …
Volumetric printing across melt electrowritten scaffolds fabricates multi‐material living constructs with tunable architecture and mechanics
Major challenges in biofabrication revolve around capturing the complex, hierarchical
composition of native tissues. However, individual 3D printing techniques have limited …
composition of native tissues. However, individual 3D printing techniques have limited …
TGF-β signaling in control of cardiovascular function
Genetic studies in animals and humans indicate that gene mutations that functionally perturb
transforming growth factor β (TGF-β) signaling are linked to specific hereditary vascular …
transforming growth factor β (TGF-β) signaling are linked to specific hereditary vascular …
Rebuilding the damaged heart: mesenchymal stem cells, cell-based therapy, and engineered heart tissue
S Golpanian, A Wolf, KE Hatzistergos… - Physiological …, 2016 - journals.physiology.org
Mesenchymal stem cells (MSCs) are broadly distributed cells that retain postnatal capacity
for self-renewal and multilineage differentiation. MSCs evade immune detection, secrete an …
for self-renewal and multilineage differentiation. MSCs evade immune detection, secrete an …
Cholesterol loading reprograms the microRNA-143/145–myocardin axis to convert aortic smooth muscle cells to a dysfunctional macrophage-like phenotype
Y Vengrenyuk, H Nishi, X Long, M Ouimet… - … , and vascular biology, 2015 - Am Heart Assoc
Objective—We previously showed that cholesterol loading in vitro converts mouse aortic
vascular smooth muscle cells (VSMC) from a contractile state to one resembling …
vascular smooth muscle cells (VSMC) from a contractile state to one resembling …
Bone marrow mesenchymal stem cells: historical overview and concepts
P Charbord - Human gene therapy, 2010 - liebertpub.com
This review describes the historical emergence of the concept of bone marrow
mesenchymal stem cells (MSCs), summarizing data on Wolf and Trentin's hematopoietic …
mesenchymal stem cells (MSCs), summarizing data on Wolf and Trentin's hematopoietic …
Differentiation of multipotent vascular stem cells contributes to vascular diseases
It is generally accepted that the de-differentiation of smooth muscle cells, from the contractile
to the proliferative/synthetic phenotype, has an important role during vascular remodelling …
to the proliferative/synthetic phenotype, has an important role during vascular remodelling …