Exercise sustains the hallmarks of health

Y Qiu, B Fernández-García, HI Lehmann, G Li… - Journal of sport and …, 2023 - Elsevier
Exercise has long been known for its active role in improving physical fitness and sustaining
health. Regular moderate-intensity exercise improves all aspects of human health and is …

Mutual interaction between endoplasmic reticulum and mitochondria in nonalcoholic fatty liver disease

J Wang, W He, PJ Tsai, PH Chen, M Ye, J Guo… - Lipids in Health and …, 2020 - Springer
Nonalcoholic fatty liver disease (NAFLD) is a common metabolic syndrome. Imbalances
between liver lipid output and input are the direct causes of NAFLD, and hepatic steatosis is …

Insulin resistance and mitochondrial dysfunction

A Gonzalez-Franquesa, ME Patti - Mitochondrial Dynamics in …, 2017 - Springer
Insulin resistance precedes and predicts the onset of type 2 diabetes (T2D) in susceptible
humans, underscoring its important role in the complex pathogenesis of this disease. Insulin …

[HTML][HTML] Physical exercise and liver “fitness”: Role of mitochondrial function and epigenetics-related mechanisms in non-alcoholic fatty liver disease

J Stevanović, J Beleza, P Coxito, A Ascensão… - Molecular …, 2020 - Elsevier
Background Modern lifestyles, especially high-caloric intake and physical inactivity,
contribute to the increased prevalence of non-alcoholic fatty liver disease (NAFLD), which …

Integrating the contributions of mitochondrial oxidative metabolism to lipotoxicity and inflammation in NAFLD pathogenesis

CC Hughey, P Puchalska, PA Crawford - Biochimica et Biophysica Acta …, 2022 - Elsevier
The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing globally. NAFLD
includes non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH). NASH is …

[HTML][HTML] Molecular mechanisms of exercise and healthspan

Y Guan, Z Yan - Cells, 2022 - mdpi.com
Healthspan is the period of our life without major debilitating diseases. In the modern world
where unhealthy lifestyle choices and chronic diseases taper the healthspan, which lead to …

Western diet causes obesity-induced nonalcoholic fatty liver disease development by differentially compromising the autophagic response

ICM Simoes, A Karkucinska-Wieckowska, J Janikiewicz… - Antioxidants, 2020 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) is characterized by the development of steatosis,
which can ultimately compromise liver function. Mitochondria are key players in obesity …

The emerging significance of mitochondrial targeted strategies in NAFLD treatment

T Zhang, Y Nie, J Wang - Life sciences, 2023 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease
worldwide, ranging from liver steatosis to nonalcoholic steatohepatitis, which ultimately …

Understanding the role of exercise in nonalcoholic fatty liver disease: ERS‐linked molecular pathways

Y Zou, Z Qi - Mediators of inflammation, 2020 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is globally prevalent and characterized by
abnormal lipid accumulation in the liver, frequently accompanied by insulin resistance (IR) …

[HTML][HTML] Maternal high-fat high-sucrose diet and gestational exercise modulate hepatic fat accumulation and liver mitochondrial respiratory capacity in mothers and …

J Stevanović-Silva, J Beleza, P Coxito, S Pereira… - Metabolism, 2021 - Elsevier
Background Maternal high-caloric nutrition and related gestational diabetes mellitus (GDM)
are associated with a high-risk for develo** metabolic complications later in life and in …