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[HTML][HTML] Histone mutations in cancer
Genes encoding histone proteins are recurrently mutated in tumor samples, and these
mutations may impact nucleosome stability, histone post-translational modification, or …
mutations may impact nucleosome stability, histone post-translational modification, or …
Oncohistones: Exposing the nuances and vulnerabilities of epigenetic regulation
Work over the last decade has uncovered a new layer of epigenetic dysregulation. It is now
appreciated that somatic missense mutations in histones, the packaging agents of genomic …
appreciated that somatic missense mutations in histones, the packaging agents of genomic …
cBAF complex components and MYC cooperate early in CD8+ T cell fate
The identification of mechanisms to promote memory T (Tmem) cells has important
implications for vaccination and anti-cancer immunotherapy,,–. Using a CRISPR-based …
implications for vaccination and anti-cancer immunotherapy,,–. Using a CRISPR-based …
Tracking chromatin state changes using nanoscale photo-proximity labelling
Interactions between biomolecules underlie all cellular processes and ultimately control cell
fate. Perturbation of native interactions through mutation, changes in expression levels or …
fate. Perturbation of native interactions through mutation, changes in expression levels or …
Cancer-associated Histone H3 N-terminal arginine mutations disrupt PRC2 activity and impair differentiation
Dysregulated epigenetic states are a hallmark of cancer and often arise from genetic
alterations in epigenetic regulators. This includes missense mutations in histones, which …
alterations in epigenetic regulators. This includes missense mutations in histones, which …
Interrogating epigenetic mechanisms with chemically customized chromatin
Genetic and genomic techniques have proven incredibly powerful for identifying and
studying molecular players implicated in the epigenetic regulation of DNA-templated …
studying molecular players implicated in the epigenetic regulation of DNA-templated …
TGM2-mediated histone transglutamination is dictated by steric accessibility
Recent studies have identified serotonylation of glutamine-5 on histone H3 (H3Q5ser) as a
novel posttranslational modification (PTM) associated with active transcription. While …
novel posttranslational modification (PTM) associated with active transcription. While …
Epigenetic modification regulates tumor progression and metastasis through EMT
T Tan, P Shi, MN Abbas, Y Wang… - International …, 2022 - spandidos-publications.com
Epigenetics is the study of heritable molecular determinants that are independent of
phenotypic features. The epigenetic features include DNA methylation, histone …
phenotypic features. The epigenetic features include DNA methylation, histone …
Pan-cancer atlas of somatic core and linker histone mutations
Recent genomic data points to a growing role for somatic mutations altering core histone
and linker histone-encoding genes in cancer. However, the prevalence and the clinical and …
and linker histone-encoding genes in cancer. However, the prevalence and the clinical and …
Oncohistones and disrupted development in pediatric-type diffuse high-grade glioma
Recurrent, clonal somatic mutations in histone H3 are molecular hallmarks that distinguish
the genetic mechanisms underlying pediatric and adult high-grade glioma (HGG), define …
the genetic mechanisms underlying pediatric and adult high-grade glioma (HGG), define …