Förster or fluorescence resonance energy transfer (FRET) technology and genetically
encoded FRET biosensors provide a powerful tool for visualizing signaling molecules in live …

Visualization of dynamic functional and molecular events in an unperturbed in vivo
environment is essential for understanding the complex biology of living organisms and of …

Genome sequencing studies have shown that human malignancies often bear mutations in
four or more driver genes, but it is difficult to recapitulate this degree of genetic complexity in …

The ideal fluorescent probe for bioimaging is bright, absorbs at long wavelengths and can
be implemented flexibly in living cells and in vivo. However, the design of synthetic …

Monomeric near-infrared (NIR) fluorescent proteins (FPs) are in high demand as protein
tags and components of biosensors for deep-tissue imaging and multicolour microscopy. We …

Stimulated emission depletion (STED) nanoscopy is a promising fluorescence microscopy to
detect unresolvable structures at the nanoscale level and then achieve a superior imaging …

Near-infrared fluorescent proteins (FPs) are in high demand for in vivo imaging. We
developed four spectrally distinct near-infrared FPs—iRFP670, iRFP682, iRFP702 and …

Bright monomeric near-infrared (NIR) fluorescent proteins (FPs) are in high demand as
protein tags for multicolor microscopy and in vivo imaging. Here we apply rational design to …

Imaging biological processes in mammalian tissues will be facilitated by fluorescent probes
with excitation and emission bands within the near-infrared optical window of high …

The ability to measure dynamic changes in neurochemicals with high spatiotemporal
resolution is essential for understanding the diverse range of functions mediated by the …