[HTML][HTML] SARS-CoV-2 Omicron variant: recent progress and future perspectives

Y Fan, X Li, L Zhang, S Wan, L Zhang… - Signal transduction and …, 2022‏ - nature.com
Since the outbreak of the coronavirus disease 2019 (COVID-19) pandemic, there have been
a few variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), one of …

[HTML][HTML] A comprehensive review of the protein subunit vaccines against COVID-19

M Heidary, VH Kaviar, M Shirani, R Ghanavati… - Frontiers in …, 2022‏ - frontiersin.org
Two years after severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), in
December 2019, the first infections were identified in Wuhan city of China. SARS-CoV-2 …

[HTML][HTML] Alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants

Q Wang, S Iketani, Z Li, L Liu, Y Guo, Y Huang… - Cell, 2023‏ - cell.com
The BQ and XBB subvariants of SARS-CoV-2 Omicron are now rapidly expanding, possibly
due to altered antibody evasion properties deriving from their additional spike mutations …

Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting

A Yisimayi, W Song, J Wang, F Jian, Y Yu, X Chen… - Nature, 2024‏ - nature.com
The continuing emergence of SARS-CoV-2 variants highlights the need to update COVID-19
vaccine compositions. However, immune imprinting induced by vaccination based on the …

Antigenicity and receptor affinity of SARS-CoV-2 BA. 2.86 spike

Q Wang, Y Guo, L Liu, LT Schwanz, Z Li, MS Nair, J Ho… - Nature, 2023‏ - nature.com
A severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron subvariant, BA.
2.86, has emerged and spread to numerous countries worldwide, raising alarm because its …

BA. 2.12. 1, BA. 4 and BA. 5 escape antibodies elicited by Omicron infection

Y Cao, A Yisimayi, F Jian, W Song, T **ao, L Wang… - Nature, 2022‏ - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron sublineages BA.
2.12. 1, BA. 4 and BA. 5 exhibit higher transmissibility than the BA. 2 lineage. The receptor …

Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies

Y Cao, J Wang, F Jian, T **ao, W Song, A Yisimayi… - Nature, 2022‏ - nature.com
Abstract The SARS-CoV-2 B. 1.1. 529 (Omicron) variant contains 15 mutations of the
receptor-binding domain (RBD). How Omicron evades RBD-targeted neutralizing antibodies …

[HTML][HTML] Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2

P Han, L Li, S Liu, Q Wang, D Zhang, Z Xu, P Han, X Li… - Cell, 2022‏ - cell.com
Summary The coronavirus disease 2019 (COVID-19) pandemic continues worldwide with
many variants arising, some of which are variants of concern (VOCs). A recent VOC, omicron …

Evolving antibody response to SARS-CoV-2 antigenic shift from XBB to JN. 1

F Jian, J Wang, A Yisimayi, W Song, Y Xu, X Chen… - Nature, 2024‏ - nature.com
The continuous evolution of SARS-CoV-2, particularly the emergence of BA. 2.86/JN. 1
lineage replacing XBB, necessitates re-evaluation of vaccine compositions 1–3. Here, we …

Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium study

KM Hastie, H Li, D Bedinger, SL Schendel… - Science, 2021‏ - science.org
Antibody-based therapeutics and vaccines are essential to combat COVID-19 morbidity and
mortality after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection …