The SARS-CoV-2 spike glycoprotein biosynthesis, structure, function, and antigenicity: implications for the design of spike-based vaccine immunogens
L Duan, Q Zheng, H Zhang, Y Niu, Y Lou… - Frontiers in …, 2020 - frontiersin.org
The ongoing pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), poses a grave threat to global public …
respiratory syndrome coronavirus 2 (SARS-CoV-2), poses a grave threat to global public …
[HTML][HTML] Exploitation of glycosylation in enveloped virus pathobiology
Y Watanabe, TA Bowden, IA Wilson… - Biochimica et Biophysica …, 2019 - Elsevier
Glycosylation is a ubiquitous post-translational modification responsible for a multitude of
crucial biological roles. As obligate parasites, viruses exploit host-cell machinery to …
crucial biological roles. As obligate parasites, viruses exploit host-cell machinery to …
[HTML][HTML] Molecular architecture of the SARS-CoV-2 virus
SARS-CoV-2 is an enveloped virus responsible for the COVID-19 pandemic. Despite recent
advances in the structural elucidation of SARS-CoV-2 proteins, the detailed architecture of …
advances in the structural elucidation of SARS-CoV-2 proteins, the detailed architecture of …
Site-specific glycan analysis of the SARS-CoV-2 spike
The emergence of the betacoronavirus, severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), represents a …
(SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), represents a …
[HTML][HTML] Unexpected receptor functional mimicry elucidates activation of coronavirus fusion
Recent outbreaks of severe acute respiratory syndrome and Middle East respiratory
syndrome, along with the threat of a future coronavirus-mediated pandemic, underscore the …
syndrome, along with the threat of a future coronavirus-mediated pandemic, underscore the …
Vulnerabilities in coronavirus glycan shields despite extensive glycosylation
Severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS)
coronaviruses (CoVs) are zoonotic pathogens with high fatality rates and pandemic …
coronaviruses (CoVs) are zoonotic pathogens with high fatality rates and pandemic …
Structural features of coronavirus SARS-CoV-2 spike protein: Targets for vaccination
A Sternberg, C Naujokat - Life sciences, 2020 - Elsevier
Various human pathogenic viruses employ envelope glycoproteins for host cell receptor
recognition and binding, membrane fusion and viral entry. The spike (S) glycoprotein of …
recognition and binding, membrane fusion and viral entry. The spike (S) glycoprotein of …
Lassa fever—the road ahead
RF Garry - Nature Reviews Microbiology, 2023 - nature.com
Lassa virus (LASV) is endemic in the rodent populations of Sierra Leone, Nigeria and other
countries in West Africa. Spillover to humans occurs frequently and results in Lassa fever, a …
countries in West Africa. Spillover to humans occurs frequently and results in Lassa fever, a …
Structural insights into the modulation of coronavirus spike tilting and infectivity by hinge glycans
Coronavirus spike glycoproteins presented on the virion surface mediate receptor binding,
and membrane fusion during virus entry and constitute the primary target for vaccine and …
and membrane fusion during virus entry and constitute the primary target for vaccine and …
A computationally designed antigen eliciting broad humoral responses against SARS-CoV-2 and related sarbecoviruses
The threat of spillovers of coronaviruses associated with the severe acute respiratory
syndrome (SARS) from animals to humans necessitates vaccines that offer broader …
syndrome (SARS) from animals to humans necessitates vaccines that offer broader …