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[HTML][HTML] An updated review on develo** small molecule kinase inhibitors using computer-aided drug design approaches
L Li, S Liu, B Wang, F Liu, S Xu, P Li… - International Journal of …, 2023 - mdpi.com
Small molecule kinase inhibitors (SMKIs) are of heightened interest in the field of drug
research and development. There are 79 (as of July 2023) small molecule kinase inhibitors …
research and development. There are 79 (as of July 2023) small molecule kinase inhibitors …
Preclinical anticipation of on-and off-target resistance mechanisms to anti-cancer drugs: a systematic review
PJ Dziubańska-Kusibab, E Nevedomskaya… - International journal of …, 2024 - mdpi.com
The advent of targeted therapies has led to tremendous improvements in treatment options
and their outcomes in the field of oncology. Yet, many cancers outsmart precision drugs by …
and their outcomes in the field of oncology. Yet, many cancers outsmart precision drugs by …
In silico binding of 2-aminocyclobutanones to SARS-CoV-2 Nsp13 helicase and demonstration of antiviral activity
The landscape of viral strains and lineages of SARS-CoV-2 keeps changing and is currently
dominated by Delta and Omicron variants. Members of the latest Omicron variants, including …
dominated by Delta and Omicron variants. Members of the latest Omicron variants, including …
[HTML][HTML] Synthesis and Antiproliferative Potential of Thiazole and 4-Thiazolidinone Containing Motifs as Dual Inhibitors of EGFR and BRAFV600E
Thiazole and thiazolidinone recur in a wide range of biologically active compounds that
reach different targets within the context of tumors and represent a promising starting point to …
reach different targets within the context of tumors and represent a promising starting point to …
A Novel FYVE Domain-Containing Protein Kinase, PsZFPK1, Plays a Critical Role in Vegetative Growth, Sporangium Formation, Oospore Production, and Virulence in …
B Ru, X Hao, W Li, Q Peng, J Miao, X Liu - Journal of Fungi, 2023 - mdpi.com
Proteins containing both FYVE and serine/threonine kinase catalytic (STKc) domains are
exclusive to protists. However, the biological function of these proteins in oomycetes has …
exclusive to protists. However, the biological function of these proteins in oomycetes has …
[HTML][HTML] Glasdegib dimaleate: Synthesis, characterization and comparison of its properties with monomaleate analogue
B Peklar, F Perdih, D Makuc, J Plavec, J Cluzeau… - Pharmaceutics, 2022 - mdpi.com
Glasdegib is a recently approved drug for the treatment of acute myeloid leukemia. It is
formulated and marketed in monomaleate salt form. In our investigation, we were able to …
formulated and marketed in monomaleate salt form. In our investigation, we were able to …