Variation within the non-coding genome influences genetic and epigenetic regulation of the human leukocyte antigen genes

T Arumugam, T Adimulam, A Gokul… - Frontiers in …, 2024 - frontiersin.org
Variation within the non-coding genome may influence the regulation and expression of
important genes involved in immune control such as the human leukocyte antigen (HLA) …

Exploring the HLA complex in autoimmunity: From the risk haplotypes to the modulation of expression

S Sartoris, G Del Pozzo - Clinical Immunology, 2024 - Elsevier
The genes map** at the HLA region show high density, strong linkage disequilibrium and
high polymorphism, which affect the association of HLA class I and class II genes with …

Reassessment of marker genes in human induced pluripotent stem cells for enhanced quality control

J Dobner, S Diecke, J Krutmann, A Prigione… - Nature …, 2024 - nature.com
Human induced pluripotent stem cells (iPSCs) have great potential in research, but
pluripotency testing faces challenges due to non-standardized methods and ambiguous …

Assessing radish health during space cultivation by gene transcription

KH Hasenstein, SP John, JP Vandenbrink - Plants, 2023 - mdpi.com
During the Advanced Plant Habitat experiment 2, radish plants were grown in two
successive grow-outs on the International Space Station (ISS) for 27 days each. On days 10 …

[HTML][HTML] Identification and characterization of two salmon louse heme peroxidases and their potential as vaccine antigens

E Gislefoss, AAA Gamil, AC Øvergård, Ø Evensen - Iscience, 2023 - cell.com
Salmon louse, Lepeophtheirus salmonis, represents major challenge for salmon farming.
Current treatments impose welfare issues and are costly, whereas prophylactic measures …

A hierarchical GNN across semantic and topological domains for predicting circRNA-microRNA interactions

J Zhou, B Ji, R Niu, X Shang, Z You - Knowledge-Based Systems, 2024 - Elsevier
Identifying circRNA-microRNA interactions (CMI) is a significant biomedical issue in recent
years. This problem provides insights into using circRNA as biomarkers, develo** cancer …

Establishment and comparison of human term placenta–derived trophoblast cells

MS Vidal Jr, E Radnaa, N Vora, K Khanipov… - Biology of …, 2024 - academic.oup.com
Research on the biology of fetal–maternal barriers has been limited by access to
physiologically relevant cells, including trophoblast cells. In this study, we describe the …

Nucleotide alterations in the HLA-C class I gene can cause aberrant splicing and marked changes in RNA levels in a polymorphic context-dependent manner

A Mizutani, S Suzuki, A Shigenari, T Sato… - Frontiers in …, 2024 - frontiersin.org
Polymorphisms of HLA genes, which play a crucial role in presenting peptides with diverse
sequences in their peptide-binding pockets, are also thought to affect HLA gene expression …

Phenotypic and gene expression characteristics of Japanese eel late-stage leptocephali and glass eels after growth on different diets with a focus on nutrient …

R Hatakeyama, M Mekuchi, H Furuita, M Satomi… - Aquaculture, 2025 - Elsevier
To evaluate the quality of glass eels that were derived from late-stage Anguilla japonica
leptocephali raised on an old-type of shark egg-based diet (SE) or a new-type of fish meal …

[HTML][HTML] A Snapshot of Early Transcriptional Changes Accompanying the Pro-Neural Phenotype Switch by NGN2, ASCL1, SOX2, and MSI1 in Human Fibroblasts: An …

EM Samoilova, DA Chudakova… - International …, 2024 - pmc.ncbi.nlm.nih.gov
Direct pro-neural reprogramming is a conversion of differentiated somatic cells to neural
cells without an intermediate pluripotency stage. It is usually achieved via ectopic …