Bone has well documented natural healing capacity that normally is sufficient to repair
fractures and other common injuries. However, the properties of bone change throughout …

Bone is a highly vascularized tissue, and its development, maturation, remodeling, and
regeneration are dependent on a tight regulation of blood vessel supply. This condition also …

Healing and regeneration of bone injuries, particularly those that are associated with large
bone defects, are a complicated process. There is growing interest in the application of …

Regenerative therapies for bone and cartilage injuries are currently unable to replicate the
complex microenvironment of native tissue. There are many tissue engineering approaches …

The controlled delivery of growth factors and cells within biomaterial carriers can enhance
and accelerate functional bone formation. The carrier system can be designed with pre …

Regenerative medicine approaches based on decellularized extracellular matrix (ECM)
scaffolds and tissues are rapidly expanding. The rationale for using ECM as a natural …

In view of their low immunogenicity, biomimetic internal environment, tissue-and organ-like
physicochemical properties, and functionalization potential, decellularized extracellular …

Chitin-derived hydrogels are commonly used in bone regeneration because of their high cell
compatibility; however, their poor mechanical properties and little knowledge of the …

Mesenchymal stem cells (MSCs) within their native environment of the stem cell niche in
bone receive biochemical stimuli from surrounding cells. These stimuli likely in fluence how …

Abstract 3D printing technique is the most sophisticated technique to produce scaffolds with
tailorable physical properties. But, these scaffolds often suffer from limited biological …