Placental origins of chronic disease
Epidemiological evidence links an individual's susceptibility to chronic disease in adult life to
events during their intrauterine phase of development. Biologically this should not be …
events during their intrauterine phase of development. Biologically this should not be …
Mechanisms of early placental development in mouse and humans
The importance of the placenta in supporting mammalian development has long been
recognized, but our knowledge of the molecular, genetic and epigenetic requirements that …
recognized, but our knowledge of the molecular, genetic and epigenetic requirements that …
Immune responses at the maternal-fetal interface
SE Ander, MS Diamond, CB Coyne - Science immunology, 2019 - science.org
Pregnancy poses an immunological challenge because a genetically distinct (nonself) fetus
must be supported within the pregnant female for the required gestational period …
must be supported within the pregnant female for the required gestational period …
Regulation of placental development and its impact on fetal growth—new insights from mouse models
The placenta is the chief regulator of nutrient supply to the growing embryo during gestation.
As such, adequate placental function is instrumental for developmental progression …
As such, adequate placental function is instrumental for developmental progression …
The uterine spiral arteries in human pregnancy: facts and controversies
R Pijnenborg, L Vercruysse, M Hanssens - Placenta, 2006 - Elsevier
Uterine spiral arteries play a vital role in supplying nutrients to the placenta and fetus, and
for this purpose they are remodelled into highly dilated vessels by the action of invading …
for this purpose they are remodelled into highly dilated vessels by the action of invading …
Investigation of human trophoblast invasion in vitro
BACKGROUND In humans, inadequate trophoblast invasion into the decidua is associated
with the 'great obstetrical syndromes' which include pre-eclampsia, foetal growth restriction …
with the 'great obstetrical syndromes' which include pre-eclampsia, foetal growth restriction …
Physiological and molecular determinants of embryo implantation
S Zhang, H Lin, S Kong, S Wang, H Wang… - Molecular aspects of …, 2013 - Elsevier
Embryo implantation involves the intimate interaction between an implantation-competent
blastocyst and a receptive uterus, which occurs in a limited time period known as the …
blastocyst and a receptive uterus, which occurs in a limited time period known as the …
[HTML][HTML] Trophoblast differentiation during embryo implantation and formation of the maternal-fetal interface
K Red-Horse, Y Zhou, O Genbacev… - The Journal of …, 2004 - Am Soc Clin Investig
Trophoblasts, the specialized cells of the placenta, play a major role in implantation and
formation of the maternal-fetal interface. Through an unusual differentiation process …
formation of the maternal-fetal interface. Through an unusual differentiation process …
The role of hypoxia in development of the Mammalian embryo
SL Dunwoodie - Developmental cell, 2009 - cell.com
Hypoxia inducible factor (HIF) is a transcription factor that acts in low-oxygen conditions. The
cellular response to HIF activation is transcriptional upregulation of a large group of genes …
cellular response to HIF activation is transcriptional upregulation of a large group of genes …
[HTML][HTML] Uterine NK cells and macrophages in pregnancy
The presence of immune cells in the placental bed is important for both mother and child.
Although various immune cells can be found in the placental bed, such as regulatory T cells …
Although various immune cells can be found in the placental bed, such as regulatory T cells …