Post-traumatic stress disorder: clinical and translational neuroscience from cells to circuits
Post-traumatic stress disorder (PTSD) is a maladaptive and debilitating psychiatric disorder,
characterized by re-experiencing, avoidance, negative emotions and thoughts, and …
characterized by re-experiencing, avoidance, negative emotions and thoughts, and …
Gut/brain axis and the microbiota
Tremendous progress has been made in characterizing the bidirectional interactions
between the central nervous system, the enteric nervous system, and the gastrointestinal …
between the central nervous system, the enteric nervous system, and the gastrointestinal …
The enduring effects of abuse and related adverse experiences in childhood: A convergence of evidence from neurobiology and epidemiology
RF Anda, VJ Felitti, JD Bremner, JD Walker… - European archives of …, 2006 - Springer
Background Childhood maltreatment has been linked to a variety of changes in brain
structure and function and stress–responsive neurobiological systems. Epidemiological …
structure and function and stress–responsive neurobiological systems. Epidemiological …
Physiology and neurobiology of stress and adaptation: central role of the brain
BS McEwen - Physiological reviews, 2007 - journals.physiology.org
The brain is the key organ of the response to stress because it determines what is
threatening and, therefore, potentially stressful, as well as the physiological and behavioral …
threatening and, therefore, potentially stressful, as well as the physiological and behavioral …
Stress and the brain: from adaptation to disease
ER De Kloet, M Joëls, F Holsboer - Nature reviews neuroscience, 2005 - nature.com
In response to stress, the brain activates several neuropeptide-secreting systems. This
eventually leads to the release of adrenal corticosteroid hormones, which subsequently feed …
eventually leads to the release of adrenal corticosteroid hormones, which subsequently feed …
Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse
PO McGowan, A Sasaki, AC D'alessio, S Dymov… - Nature …, 2009 - nature.com
Maternal care influences hypothalamic-pituitary-adrenal (HPA) function in the rat through
epigenetic programming of glucocorticoid receptor expression. In humans, childhood abuse …
epigenetic programming of glucocorticoid receptor expression. In humans, childhood abuse …
Psychological stress in childhood and susceptibility to the chronic diseases of aging: moving toward a model of behavioral and biological mechanisms.
Among people exposed to major psychological stressors in early life, there are elevated
rates of morbidity and mortality from chronic diseases of aging. The most compelling data …
rates of morbidity and mortality from chronic diseases of aging. The most compelling data …
Stress and depression
C Hammen - Annu. Rev. Clin. Psychol., 2005 - annualreviews.org
Improved methods of assessment and research design have established a robust and
causal association between stressful life events and major depressive episodes. The …
causal association between stressful life events and major depressive episodes. The …
Neurobiology of depression
Current treatments for depression are inadequate for many individuals, and progress in
understanding the neurobiology of depression is slow. Several promising hypotheses of …
understanding the neurobiology of depression is slow. Several promising hypotheses of …
Early-life inflammation promotes depressive symptoms in adolescence via microglial engulfment of dendritic spines
P Cao, C Chen, A Liu, Q Shan, X Zhu, C Jia, X Peng… - Neuron, 2021 - cell.com
Early-life inflammation increases the risk for depression in later life. Here, we demonstrate
how early-life inflammation causes adolescent depressive-like symptoms: by altering the …
how early-life inflammation causes adolescent depressive-like symptoms: by altering the …