Advanced ultrasound technology and functional biomaterials can be used to achieve
precision drug therapy in different aspects such as dose, space, and/or time. At present …

Solid tumor pathology, characterized by abnormalities in the tumor microenvironment (TME),
challenges therapeutic effectiveness. Mechanical factors, including increased tumor stiffness …

Highlights•Bacteria can act as engineered live therapeutics for tumor targeting.•New
strategies are needed to improve tumor colonization without causing widespread …

Tumor immunotherapy has emerged as a promising approach to tumor treatment. Currently,
immune adjuvant-based therapeutic modalities are rarely curative in solid tumors owing to …

The lack of properly perfused blood vessels within tumors can significantly hinder the
distribution of drugs, leading to reduced treatment effectiveness and having a negative …

The use of drug-loaded microbubbles for targeted drug delivery, particularly in cancer
treatment, has been extensively studied in recent years. However, the loading capacity of …

Lung cancer is one of the most common cancers and a leading cause of death, with poor
prognosis and high unmet clinical need. Chemotherapy is a common part of the treatment …

Embryonal tumors of the nervous system are neoplasms predominantly affecting the
pediatric population. Among the most common and aggressive ones are neuroblastoma …

The delivery of nanoparticles to tumors has been shown preclinically to be improved by
microbubble-mediated ultrasound. However, the mechanisms and biological effects are not …

Objective Ultrasound in combination with microbubbles can enhance accumulation and
improve the distribution of various therapeutic agents in tumor tissue, leading to improved …