Titanium dioxide nanoparticles in food and personal care products—What do we know about their safety?

J Musial, R Krakowiak, DT Mlynarczyk, T Goslinski… - Nanomaterials, 2020 - mdpi.com
Titanium dioxide (TiO2) is a material of diverse applications commonly used as a food
additive or cosmetic ingredient. Its prevalence in products of everyday use, especially in …

Possible adverse effects of food additive E171 (titanium dioxide) related to particle specific human toxicity, including the immune system

NS Bischoff, TM de Kok, DTHM Sijm… - International journal of …, 2020 - mdpi.com
Titanium dioxide (TiO2) is used as a food additive (E171) and can be found in sauces,
icings, and chewing gums, as well as in personal care products such as toothpaste and …

The importance of the IL‐1 family of cytokines in nanoimmunosafety and nanotoxicology

G Zhang, W Luo, W Yang, S Li, D Li… - Wiley Interdisciplinary …, 2022 - Wiley Online Library
Engineered nanomaterials (ENMs) to which humans are exposed intentionally as
nanomedicines or unintentionally as invaders, may elicit unforeseen immune reactions. An …

Neuroinflammation is induced by tongue-instilled ZnO nanoparticles via the Ca2+-dependent NF-κB and MAPK pathways

H Liang, A Chen, X Lai, J Liu, J Wu, Y Kang… - Particle and Fibre …, 2018 - Springer
Background The extensive biological applications of zinc oxide nanoparticles (ZnO NPs) in
stomatology have created serious concerns about their biotoxicity. In our previous study …

Metal oxide nanoparticles in therapeutic regulation of macrophage functions

MS Dukhinova, AY Prilepskii, AA Shtil, VV Vinogradov - Nanomaterials, 2019 - mdpi.com
Macrophages are components of the innate immune system that control a plethora of
biological processes. Macrophages can be activated towards pro-inflammatory (M1) or anti …

Formation of a protein corona influences the biological identity of nanomaterials

D Nierenberg, AR Khaled… - Reports of Practical …, 2018 - journals.viamedica.pl
The development and testing of nanomaterials is an area of interest due to promising
diagnostic and therapeutic applications in the treatment of diseases like cancer or …

Metal nanomaterials: Immune effects and implications of physicochemical properties on sensitization, elicitation, and exacerbation of allergic disease

KA Roach, AB Stefaniak, JR Roberts - Journal of …, 2019 - Taylor & Francis
The recent surge in incorporation of metallic and metal oxide nanomaterials into consumer
products and their corresponding use in occupational settings have raised concerns over …

Addressing nanomaterial immunosafety by evaluating innate immunity across living species

D Boraschi, A Alijagic, M Auguste, F Barbero, E Ferrari… - Small, 2020 - Wiley Online Library
The interaction of a living organism with external foreign agents is a central issue for its
survival and adaptation to the environment. Nanosafety should be considered within this …

Nanotherapeutic heterogeneity: sources, effects, and solutions

J Morla‐Folch, A Ranzenigo, ZA Fayad, AJP Teunissen - Small, 2024 - Wiley Online Library
Nanomaterials have revolutionized medicine by enabling control over drugs'
pharmacokinetics, biodistribution, and biocompatibility. However, most nanotherapeutic …

Investigating Chaperonin-Containing TCP-1 subunit 2 as an essential component of the chaperonin complex for tumorigenesis

AE Showalter, AC Martini, D Nierenberg, K Hosang… - Scientific reports, 2020 - nature.com
Abstract Chaperonin-containing TCP-1 (CCT or TRiC) is a multi-subunit complex that folds
many of the proteins essential for cancer development. CCT is expressed in diverse cancers …