Analytical and immunological methodologies and occasionally both methodologies have
been applied to detect and quantify 3-nitrotyrosine in almost every major organ system. In …

The nitration of free tyrosine or protein tyrosine residues generates 3-nitrotyrosine the
detection of which has been utilised as a footprint for the in vivo formation of peroxynitrite …

Tyrosine nitration is a widely used marker of peroxynitrite (ONOO−) produced from the
reaction of nitric oxide with superoxide. Pfeiffer and Mayer (Pfeiffer, S., and Mayer, B.(1998) …

Since its initial discovery as an endogenously produced bioactive mediator, nitric oxide (•
NO) has been found to play a critical role in the cellular function of nearly all organ systems …

Recent studies from this laboratory have demonstrated that human manganese superoxide
dismutase (MnSOD) is a target for tyrosine nitration in several chronic inflammatory diseases …

NO2Tyr (3-Nitrotyrosine) is a modified amino acid that is formed by nitric oxide-derived
species and has been implicated in the pathology of diverse human diseases. Nitration of …

Homogenates from rat spleen and lung could modify nitrotyrosine-containing BSA. With
incubation, nitrotyrosine-containing BSA lost its epitope to a monoclonal antibody that …

Formation of peroxynitrite from NO and O⨪ 2 is considered an important trigger for cellular
tyrosine nitration under pathophysiological conditions. However, this view has been …

Inflammation is characterized by increased nitric oxide production. Nitrotyrosine has recently
been suggested to be useful as a marker for NO-mediated tissue damage. In context of the …

Peroxynitrite (ONOO−), formed by the reaction between nitric oxide (· NO) and superoxide,
has been implicated in the etiology of numerous disease processes. Low molecular weight …