Red blood cell (RBC) aging in the blood bank is characterized by the accumulation of a
significant number of biochemical and morphologic alterations. Recent mass spectrometry …

Mature human erythrocytes are dependent on anerobic glycolysis, ie catabolism (oxidation)
of one glucose molecule to produce two ATP and two lactate molecules. Proliferating tumor …

This phase 1/2 study assessed the safety, tolerability, and preliminary efficacy of the oral
proteasome inhibitor (PI) ixazomib in patients with relapsed/refractory immunoglobulin light …

Diabetes is associated with a dramatic mortality rate due to its vascular complications.
Chronic hyperglycemia in diabetes leads to enhanced glycation of erythrocytes and …

Well-studied and promising antimicrobial peptides (AMPs), with potent bactericidal activity,
in vitro, have yet to have a significant impact in human medicine beyond topical applications …

Functional analysis of essential genes in the malarial parasite, Plasmodium, is hindered by
lack of efficient strategies for conditional protein regulation. We report the development of a …

Faster acclimatization to high altitude upon re-ascent is seen in humans; however, the
molecular basis for this enhanced adaptive response is unknown. We report that in healthy …

The chemical understanding of biological processes provides not only a deeper insight but
also a solution to abnormal biological functioning. Protein degradation, a natural biological …

Emerging studies provide new data shedding some light on the complex and pivotal role of
red blood cells (RBCs) in nitric oxide (NO) metabolism and paracrine regulation of …

Intracellular pathogens mobilize host signaling pathways of their host cell to promote their
own survival. Evidence is emerging that signal transduction elements are activated in a …