The conceptual evolution of nicotinamide adenine dinucleotide (NAD+) from being seen as
a simple metabolic cofactor to a pivotal cosubstrate for proteins regulating metabolism and …

Nicotinamide adenine dinucleotide (NAD), the cell's hydrogen carrier for redox enzymes, is
well known for its role in redox reactions. More recently, it has emerged as a signaling …

Mitochondria require nicotinamide adenine dinucleotide (NAD+) to carry out the
fundamental processes that fuel respiration and mediate cellular energy transduction …

NAD+ is a pivotal metabolite involved in cellular bioenergetics, genomic stability,
mitochondrial homeostasis, adaptive stress responses, and cell survival. Multiple NAD+ …

Research on the biology of NAD+ has been gaining momentum, providing many critical
insights into the pathogenesis of age-associated functional decline and diseases. In …

Nicotinamide adenine dinucleotide (NAD+) is modulated by conditions of metabolic stress
and has been reported to decline with aging in preclinical models, but human data are …

Nicotinamide adenine dinucleotide (NAD+) is a central metabolite involved in energy and
redox homeostasis as well as in DNA repair and protein deacetylation reactions …

The role in longevity and healthspan of nicotinamide (NAM), the physiological precursor of
NAD+, is elusive. Here, we report that chronic NAM supplementation improves healthspan …

Background: Myocardial metabolic impairment is a major feature in chronic heart failure. As
the major coenzyme in fuel oxidation and oxidative phosphorylation and a substrate for …

Nicotinamide riboside (NR) has recently become one of the most studied nicotinamide
adenine dinucleotide (NAD+) precursors, due to its numerous potential health benefits …