Breast cancer, emerging malignancy is common among women due to overexpression of
estrogen. Estrogens are biosynthesized from androgens by aromatase, a cytochrome P450 …

Background: Cancer accounts for several deaths each year. There are multiple FDA
approved drugs for cancer treatments. Due to the severe side effects and multiple drug …

Breast cancer is the most frequent female cancer and second cause of cancer-related
deaths among women around the world. Two thirds of breast cancer patients have hormone …

An array of newly synthesized thieno [3, 2-d] pyrimidine-based derivatives and
thienotriazolopyrimidines hybridized with some pharmacophoric anticancer fragments were …

In the last step of estrogen biosynthesis, aromatase enzyme catalyzes the conversion of
androgens to estrogens. Aromatase inhibition is an important way to control estrogen …

Aromatase is involved in the biosynthesis of estrogen and thus is a critical target for breast
cancer. In this study, to identify new aromatase enzyme inhibitors, seven 3‐[4‐(5‐methyl‐1H …

New 2-substituted benzoxazole derivatives were synthesized and screened for their in vitro
anti-proliferative activities against MCF-7 and MDA-MB-231 cell lines. Compounds 4b, 4d …

In this study, a series of imidazole derivatives was designed, synthesized, and evaluated for
in vitro biological activity on the human breast cancer cell line MCF7 by MTT assay. To …

Abstract New benzoxazole derivatives containing 1, 3, 4-oxadiazole, 1, 2, 4-triazole or
triazolothiadiazine rings were synthesized and screened for their in vitro antiproliferative …

An efficient Rh/Pd relay catalyzed intermolecular and cascade intramolecular
hydroamination for the synthesis of exclusive trans 1-indolyl dihydronaphthalenols (up to …