Colonization factors of human and animal-specific enterotoxigenic Escherichia coli (ETEC)

A von Mentzer, AM Svennerholm - Trends in Microbiology, 2024 - cell.com
Colonization factors (CFs) are major virulence factors of enterotoxigenic Escherichia coli
(ETEC). This pathogen is among the most common causes of bacterial diarrhea in children …

[HTML][HTML] The role of vaccines in reducing antimicrobial resistance: A review of potential impact of vaccines on AMR and insights across 16 vaccines and pathogens

M Hasso-Agopsowicz, E Sparrow, AM Cameron, H Sati… - Vaccine, 2024 - Elsevier
Abstract In 2019, an estimated 4.95 million deaths were linked to antimicrobial resistance
(AMR). Vaccines can prevent many of these deaths by averting both drug-sensitive and …

[HTML][HTML] Safety, tolerability, and immunogenicity of an oral inactivated ETEC vaccine (ETVAX®) with dmLT adjuvant in healthy adults and children in Zambia: An age …

N Sukwa, C Mubanga, LM Hatyoka… - Vaccine, 2023 - Elsevier
Abstract Background Enterotoxigenic Escherichia coli (ETEC) is an important cause of
moderate to severe diarrhoea in children for which there is no licensed vaccine. We …

Age-dependent pathogenic profiles of enterotoxigenic Escherichia coli diarrhea in Bangladesh

M Akhtar, YA Begum, S Isfat Ara Rahman… - Frontiers in Public …, 2024 - frontiersin.org
Background Age plays a significant role in susceptibility to enterotoxigenic Escherichia coli
(ETEC) infections, yet the distribution of ETEC virulence factors across age groups remains …

Epidemiology of Enterotoxigenic Escherichia coli among Children and Adults Seeking Care at Hospitals in Two Geographically Distinct Rural Areas in Bangladesh

S Chakraborty, FT Johura, M Sultana, X Zhang… - Microorganisms, 2024 - mdpi.com
Enterotoxigenic Escherichia coli (ETEC) infections undeniably continue to have substantial
morbidity and mortality in younger children; however, limited data are available on the …

[HTML][HTML] A Perspective on the Strategy for Advancing ETVAX®, An Anti-ETEC Diarrheal Disease Vaccine, into a Field Efficacy Trial in Gambian Children: Rationale …

MJ Hossain, AM Svennerholm, N Carlin… - Microorganisms, 2023 - mdpi.com
For the first time in over 20 years, an Enterotoxigenic Escherichia coli (ETEC) vaccine
candidate, ETVAX®, has advanced into a phase 2b field efficacy trial for children 6–18 …

Use of a TaqMan Array Card for identification of enterotoxins and colonization factors directly from stool samples in an enterotoxigenic E. coli vaccine study

J Liu, TS Jokiranta, N Carlin, S Stroup… - Microbiology …, 2025 - journals.asm.org
Enterotoxigenic Escherichia coli (ETEC) is a leading cause of childhood and travelers'
diarrhea. The vaccine candidate ETVAX encompasses several ETEC colonization factors …

Application of a Novel Proteomic Microarray Reveals High Exposure to Diarrhoeagenic Escherichia coli among Children in Zambia Participating in a Phase I Clinical …

K Mwape, C Mubanga, ON Chilyabanyama, K Chibesa… - Microorganisms, 2024 - mdpi.com
Diarrhoeagenic E. coli (DEC) significantly contributes to the burden of diarrhoea among
children. Currently, there is no approved vaccine against DEC, but several vaccines against …

[HTML][HTML] Seroprevalence Study of Conserved Enterotoxigenic Escherichia coli Antigens in Globally Diverse Populations

FM Kuhlmann, V Grigura, TJ Vickers, MG Prouty… - Microorganisms, 2023 - mdpi.com
Enterotoxigenic Escherichia coli (ETEC) are common causes of infectious diarrhea among
young children of low-and middle-income countries (LMICs) and travelers to these regions …