Reticular pseudodrusen: a critical phenotype in age-related macular degeneration
Reticular pseudodrusen (RPD), or subretinal drusenoid deposits (SDD), refer to distinct
lesions that occur in the subretinal space. Over the past three decades, their presence in …
lesions that occur in the subretinal space. Over the past three decades, their presence in …
IL-1 family members mediate cell death, inflammation and angiogenesis in retinal degenerative diseases
Inflammation underpins and contributes to the pathogenesis of many retinal degenerative
diseases. The recruitment and activation of both resident microglia and recruited …
diseases. The recruitment and activation of both resident microglia and recruited …
Single-cell RNA-seq reveals the transcriptional landscape and heterogeneity of aortic macrophages in murine atherosclerosis
Rationale: It is assumed that atherosclerotic arteries contain several macrophage subsets
endowed with specific functions. The precise identity of these subsets is poorly …
endowed with specific functions. The precise identity of these subsets is poorly …
[HTML][HTML] Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma
Summary The apolipoprotein E4 (APOE4) allele is associated with an increased risk of
Alzheimer disease and a decreased risk of glaucoma, but the underlying mechanisms …
Alzheimer disease and a decreased risk of glaucoma, but the underlying mechanisms …
[HTML][HTML] VEGFR1 signaling in retinal angiogenesis and microinflammation
Five vascular endothelial growth factor receptor (VEGFR) ligands (VEGF-A,-B,–C,-D, and
placental growth factor [PlGF]) constitute the VEGF family. VEGF-A binds VEGF receptors 1 …
placental growth factor [PlGF]) constitute the VEGF family. VEGF-A binds VEGF receptors 1 …
[HTML][HTML] Dynamic lipid turnover in photoreceptors and retinal pigment epithelium throughout life
The retinal pigment epithelium-photoreceptor interphase is renewed each day in a stunning
display of cellular interdependence. While photoreceptors use photosensitive pigments to …
display of cellular interdependence. While photoreceptors use photosensitive pigments to …
Exploring the pathogenesis of age-related macular degeneration: A review of the interplay between retinal pigment epithelium dysfunction and the innate immune …
JHC Wong, JYW Ma, AI Jobling, A Brandli… - Frontiers in …, 2022 - frontiersin.org
Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss in the
older population. Classical hallmarks of early and intermediate AMD are accumulation of …
older population. Classical hallmarks of early and intermediate AMD are accumulation of …
Progression of geographic atrophy in age-related macular degeneration: AREDS2 report number 16
Purpose To analyze the prevalence, incidence, and clinical characteristics of eyes with
geographic atrophy (GA) in age-related macular degeneration (AMD), including clinical and …
geographic atrophy (GA) in age-related macular degeneration (AMD), including clinical and …
[HTML][HTML] Oxidative stress, innate immunity, and age-related macular degeneration
PX Shaw, T Stiles, C Douglas, D Ho, W Fan… - AIMS molecular …, 2016 - ncbi.nlm.nih.gov
Age-related macular degeneration (AMD) is a leading cause of vision loss affecting tens of
millions of elderly worldwide. Early AMD is characterized by the appearance of soft drusen …
millions of elderly worldwide. Early AMD is characterized by the appearance of soft drusen …
The role of inflammation in retinal neurodegeneration and degenerative diseases
Retinal neurodegeneration is predominantly reported as the apoptosis or impaired function
of the photoreceptors. Retinal degeneration is a major causative factor of irreversible vision …
of the photoreceptors. Retinal degeneration is a major causative factor of irreversible vision …