Over the past decade, the identification of cancer-associated factors has been a subject of
primary interest not only for understanding the basic mechanisms of tumorigenesis but also …

Aminoacyl-tRNA synthetases (AARSs) are the enzymes that catalyze the aminoacylation
reaction by covalently linking an amino acid to its cognate tRNA in the first step of protein …

The aminoacyl‐tRNA synthetases are prominently known for their classic function in the first
step of protein synthesis, where they bear the responsibility of setting the genetic code. Each …

Translational fidelity is critical for microbial fitness, survival and stress responses. Much
remains unknown about the genetic and environmental control of translational fidelity and its …

Acinetobacter baumannii is a worldwide Gram-negative bacterium with a high resistance
rate, responsible for a broad spectrum of hospital-acquired infections. A computational …

Mistranslation broadly encompasses the introduction of errors during any step of protein
synthesis, leading to the incorporation of an amino acid that is different from the one …

Biochemistry and molecular biology rely on the recognition of structural complementarity
between molecules. Molecular interactions must be both quickly reversible, ie, tenuous, and …

Over the past two decades, synthetic biological systems have revolutionized the study of
cellular physiology. The ability to site‐specifically incorporate biologically relevant non …

Accurate flow of genetic information from DNA to protein requires faithful translation. An
increased level of translational errors (mistranslation) has therefore been widely considered …

Increasing resistance to antibiotics is a major problem worldwide and provides the stimulus
for development of new bacterial inhibitors with preferably different modes of action. In …