As brutally demonstrated by the COVID-19 pandemic, an effective immune system is
essential for survival. Developed over evolutionary time, viral nucleic acid detection is a …

The cGAS–STING signalling pathway has emerged as a key mediator of inflammation in the
settings of infection, cellular stress and tissue damage. Underlying this broad involvement of …

Juvenile idiopathic arthritis (JIA) is an umbrella term for arthritis of unknown origin, lasting
for> 6 weeks with onset before 16 years of age. JIA is the most common chronic …

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that primarily affects
the lining of the synovial joints and is associated with progressive disability, premature …

Idiopathic pulmonary fibrosis (IPF) is a progressive, and ultimately fatal, chronic interstitial
lung disease characterized by enhanced extracellular matrix deposition. Repetitive alveolar …

Ubiquitylation is an essential post-translational modification that regulates intracellular
signalling networks by triggering proteasomal substrate degradation, changing the activity of …

Patients with rheumatoid arthritis can be divided into two major subsets characterized by the
presence versus absence of antibodies to citrullinated protein antigens (ACPAs) and of …

Background Gain-of-function mutations in STING1 underlie a type I interferonopathy termed
SAVI (STING-associated vasculopathy with onset in infancy). This severe disease is variably …

Heterozygous missense mutations in coatomer protein subunit α, COPA, cause a syndrome
overlap** clinically with type I IFN-mediated disease due to gain-of-function in STING, a …

Type I interferon (IFN) signalling is tightly controlled. Upon recognition of DNA by cyclic GMP-
AMP synthase (cGAS), stimulator of interferon genes (STING) translocates along the …