Cellular metabolism orchestrates the intricate use of tissue fuels for catabolism and
anabolism to generate cellular energy and structural components. The emerging field of …

Macrophages are a heterogeneous population of immune cells playing several and diverse
functions in homeostatic and immune responses. The broad spectrum of macrophage …

Diabetes mellitus type II and obesity are two important causes of death in modern society.
They are characterized by low-grade chronic inflammation and metabolic dysfunction (meta …

Macrophage polarization refers to the process by which macrophages can produce two
distinct functional phenotypes: M1 or M2. The balance between both strongly affects the …

A striking change has happened in the field of immunology whereby specific metabolic
processes have been shown to be a critical determinant of immune cell activation. Multiple …

Profound metabolic changes are characteristic of macrophages during classical activation
and have been implicated in this phenotype. Here we demonstrate that nitric oxide (NO) …

The inhibitory receptor PD-1 suppresses T cell activation by recruiting the phosphatase SHP-
2. However, mice with a T-cell-specific deletion of SHP-2 do not have improved antitumor …

Toll-like receptor (TLR) activation induces inflammatory responses in macrophages by
activating temporally defined transcriptional cascades. Whether concurrent changes in the …

Macrophages are innate immune cells that adopt diverse activation states in response to
their microenvironment. Editing macrophage activation to dampen inflammatory diseases by …

Metabolic reprogramming has become a key focus for both immunologists and cancer
biologists, with exciting advances providing new insights into the mechanisms underlying …