Tumors produce glucocorticoids by metabolite recycling, not synthesis, and activate Tregs to promote growth

MD Taves, S Otsuka, MA Taylor… - The Journal of …, 2023 - Am Soc Clin Investig
Glucocorticoids are steroid hormones with potent immunosuppressive properties. Their
primary source is the adrenals, where they are generated via de novo synthesis from …

[HTML][HTML] Spectrum of delayed post-hypoxic leukoencephalopathy syndrome: A systematic review

BS Srichawla… - World Journal of Clinical …, 2024 - pmc.ncbi.nlm.nih.gov
BACKGROUND Delayed post hypoxic leukoencephalopathy syndrome (DPHLS), also
known as Grinker's myelinopathy, is a rare but significant neurological condition that …

Efficacy of epidural steroid injection in the treatment of sciatica secondary to lumbar disc herniation: a systematic review and meta-analysis

J Zhang, R Zhang, Y Wang, X Dang - Frontiers in Neurology, 2024 - frontiersin.org
Epidural steroid injection for the treatment of sciatica caused by disc herniation is
increasingly used worldwide, but its effectiveness remains controversial. The review aiming …

Insight into the Interaction Mechanism of Vitamin D against Metabolic Syndrome: A Meta-Analysis and In Silico Study

Y **a, Y Yu, Y Zhao, Z Deng, L Zhang, G Liang - Foods, 2023 - mdpi.com
Highlights What are the main findings? In total, 14 core genes for vitamin D against MetS are
obtained via enrichment analysis. Van der Waals forces are the main interactions to sustain …

[HTML][HTML] De novo steroidogenesis in tumor cells drives bone metastasis and osteoclastogenesis

LF Sandor, JB Huh, P Benko, T Hiraga, S Poliska… - Cell Reports, 2024 - cell.com
Osteoclasts play a central role in cancer-cell-induced osteolysis, but the molecular
mechanisms of osteoclast activation during bone metastasis formation are incompletely …

Local Effects of Steroid Hormones within the Bone Microenvironment

LF Sandor, R Ragacs, DS Gyori - International Journal of Molecular …, 2023 - mdpi.com
Steroid hormone production via the adrenal cortex, gonads, and placenta (so-called
glandular steroidogenesis) is responsible for the endocrine control of the body's …

Structural analysis of melanosomes in living mammalian cells using scanning electron-assisted dielectric microscopy with deep neural network

T Okada, T Iwayama, T Ogura, S Murakami… - Computational and …, 2023 - Elsevier
Melanins are the main pigments found in mammals. Their synthesis and transfer to
keratinocytes have been widely investigated for many years. However, analysis has been …

[HTML][HTML] Potent Anti-Cancer Activity of 1-Dehydrodiosgenone from the Product of Microbial Transformation of Steroid Saponins

Q Li, S Feng, Y Zhang, F Mou, T Guo, B Qin… - International Journal of …, 2024 - mdpi.com
Steroids are extensively used in the pharmaceutical industry as industrial raw materials for
the production of anti-inflammatory and anti-tumor drugs. Microbial transformation, an …

[HTML][HTML] Research on Bone Cells in Health and Disease

DS Győri - International Journal of Molecular Sciences, 2024 - mdpi.com
Bone-forming osteoblasts, osteocytes, and bone-resorbing osteoclasts are responsible for
life-long skeletal remodeling. Their abnormal function contributes to the development of …

The use of metabolomics as a tool to compare the regulatory mechanisms in the cecum, ileum, and jejunum in healthy rabbits and with diarrhea

Z Liu, J Shao, S Lai, J Wang, K Zhao, T Tang, M Wang - Animals, 2022 - mdpi.com
Simple Summary The problems caused by antibiotic abuse have swept the world, and the
Chinese government has responded to calls for a comprehensive ban on antibiotics …