Tumors produce glucocorticoids by metabolite recycling, not synthesis, and activate Tregs to promote growth
MD Taves, S Otsuka, MA Taylor… - The Journal of …, 2023 - Am Soc Clin Investig
Glucocorticoids are steroid hormones with potent immunosuppressive properties. Their
primary source is the adrenals, where they are generated via de novo synthesis from …
primary source is the adrenals, where they are generated via de novo synthesis from …
[HTML][HTML] Spectrum of delayed post-hypoxic leukoencephalopathy syndrome: A systematic review
BS Srichawla… - World Journal of Clinical …, 2024 - pmc.ncbi.nlm.nih.gov
BACKGROUND Delayed post hypoxic leukoencephalopathy syndrome (DPHLS), also
known as Grinker's myelinopathy, is a rare but significant neurological condition that …
known as Grinker's myelinopathy, is a rare but significant neurological condition that …
Efficacy of epidural steroid injection in the treatment of sciatica secondary to lumbar disc herniation: a systematic review and meta-analysis
J Zhang, R Zhang, Y Wang, X Dang - Frontiers in Neurology, 2024 - frontiersin.org
Epidural steroid injection for the treatment of sciatica caused by disc herniation is
increasingly used worldwide, but its effectiveness remains controversial. The review aiming …
increasingly used worldwide, but its effectiveness remains controversial. The review aiming …
Insight into the Interaction Mechanism of Vitamin D against Metabolic Syndrome: A Meta-Analysis and In Silico Study
Y **a, Y Yu, Y Zhao, Z Deng, L Zhang, G Liang - Foods, 2023 - mdpi.com
Highlights What are the main findings? In total, 14 core genes for vitamin D against MetS are
obtained via enrichment analysis. Van der Waals forces are the main interactions to sustain …
obtained via enrichment analysis. Van der Waals forces are the main interactions to sustain …
[HTML][HTML] De novo steroidogenesis in tumor cells drives bone metastasis and osteoclastogenesis
LF Sandor, JB Huh, P Benko, T Hiraga, S Poliska… - Cell Reports, 2024 - cell.com
Osteoclasts play a central role in cancer-cell-induced osteolysis, but the molecular
mechanisms of osteoclast activation during bone metastasis formation are incompletely …
mechanisms of osteoclast activation during bone metastasis formation are incompletely …
Local Effects of Steroid Hormones within the Bone Microenvironment
LF Sandor, R Ragacs, DS Gyori - International Journal of Molecular …, 2023 - mdpi.com
Steroid hormone production via the adrenal cortex, gonads, and placenta (so-called
glandular steroidogenesis) is responsible for the endocrine control of the body's …
glandular steroidogenesis) is responsible for the endocrine control of the body's …
Structural analysis of melanosomes in living mammalian cells using scanning electron-assisted dielectric microscopy with deep neural network
Melanins are the main pigments found in mammals. Their synthesis and transfer to
keratinocytes have been widely investigated for many years. However, analysis has been …
keratinocytes have been widely investigated for many years. However, analysis has been …
[HTML][HTML] Potent Anti-Cancer Activity of 1-Dehydrodiosgenone from the Product of Microbial Transformation of Steroid Saponins
Q Li, S Feng, Y Zhang, F Mou, T Guo, B Qin… - International Journal of …, 2024 - mdpi.com
Steroids are extensively used in the pharmaceutical industry as industrial raw materials for
the production of anti-inflammatory and anti-tumor drugs. Microbial transformation, an …
the production of anti-inflammatory and anti-tumor drugs. Microbial transformation, an …
[HTML][HTML] Research on Bone Cells in Health and Disease
DS Győri - International Journal of Molecular Sciences, 2024 - mdpi.com
Bone-forming osteoblasts, osteocytes, and bone-resorbing osteoclasts are responsible for
life-long skeletal remodeling. Their abnormal function contributes to the development of …
life-long skeletal remodeling. Their abnormal function contributes to the development of …
The use of metabolomics as a tool to compare the regulatory mechanisms in the cecum, ileum, and jejunum in healthy rabbits and with diarrhea
Z Liu, J Shao, S Lai, J Wang, K Zhao, T Tang, M Wang - Animals, 2022 - mdpi.com
Simple Summary The problems caused by antibiotic abuse have swept the world, and the
Chinese government has responded to calls for a comprehensive ban on antibiotics …
Chinese government has responded to calls for a comprehensive ban on antibiotics …