CYP17A1 is an enzyme that plays a major role in steroidogenesis and is critically involved in
the biosynthesis of steroid hormones. Therefore, it remains an attractive target in several …

Cytochrome P450 and other families of drug-metabolizing enzymes are commonly thought
of and studied for their ability to metabolize xenobiotics and other foreign entities as they are …

Metabolic control is mediated by the dynamic assemblies and function of multiple redox
enzymes. A key element in these assemblies, the P450 oxidoreductase (POR), donates …

The discovery and repurposing of drugs require a deep understanding of the mechanism of
drug action (MODA). Existing computational methods mainly model MODA with the protein …

Turmeric, a popular ingredient in the cuisine of many Asian countries, comes from the roots
of the Curcuma longa and is known for its use in Chinese and Ayurvedic medicine. Turmeric …

Endocrine-disrupting chemicals (EDCs) may impact the development of prostate cancer
(PCa) by altering the steroid metabolism. Although their exact mechanism of action in …

Abstract Cytochrome P450 (P450, CYP) enzymes have long been of interest due to their
roles in the metabolism of drugs, pesticides, pro-carcinogens, and other xenobiotic …

In the search for new and effective treatments of breast and prostate cancer, a series of
hybrid compounds based on tamoxifen, estrogens, and artemisinin were successfully …

Adrenal steroidogenesis has, for decades, been depicted as three biosynthesis pathways–
the mineralocorticoid, glucocorticoid and androgen pathways with aldosterone, cortisol and …

Cytochrome b 5 (b 5) is known to stimulate some catalytic activities of cytochrome P450
(P450, CYP) enzymes, although mechanisms still need to be defined. The reactions most …