Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, is overexpressed and
activated in many cancer types. FAK regulates diverse cellular processes, including growth …

Focal adhesion kinase (FAK) is a cytoplasmic protein tyrosine kinase that is overexpressed
and activated in several advanced-stage solid cancers. FAK promotes tumour progression …

Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase that plays critical roles in
integrin-mediated signal transductions and also participates in signaling by other cell …

A central question in cell biology is how membrane-spanning receptors transmit
extracellular signals inside cells to modulate cell adhesion and motility. Focal adhesion …

Proper patterning of the nervous system requires that develo** axons find appropriate
postsynaptic partners; this entails microns to meters of extension through an extracellular …

Focal adhesions lie at the convergence of integrin adhesion, signaling and the actin
cytoskeleton. Cells modify focal adhesions in response to changes in the molecular …

Cellular interactions with extracellular matrix play essential roles in tumor initiation,
progression and metastasis. Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase …

Matrix and tissue rigidity guides many cellular processes, including the differentiation of
stem cells and the migration of cells in health and disease. Cells actively and transiently test …

Focal adhesion kinase (FAK) is a cytoplasmic nonreceptor tyrosine kinase that enables
activation by growth factor receptors or integrins in various types of human cancers. The …

Focal adhesion kinase (FAK) is a scaffold and tyrosine kinase protein that binds to itself and
cellular partners through its four-point-one, ezrin, radixin, moesin (FERM) domain. Recent …