Magnesium is essential to the proper functioning of numerous cellular processes.
Magnesium ion (Mg 2+) deficits, as reflected in hypomagnesemia, can cause neuromuscular …

Cortical bone structure is a crucial determinant of bone strength, yet for many years studies
of novel genes and cell signalling pathways regulating bone strength have focused on the …

FAM111A, a serine protease, plays roles in DNA replication and antiviral defense. Missense
mutations in the catalytic domain cause hyper-autocleavage and are associated with genetic …

Persistent protein obstacles on genomic DNA, such as DNA-protein crosslinks (DPCs) and
tight nucleoprotein complexes, can block replication forks. DPCs can be removed by the …

Proteins covalently attached to DNA, also known as DNA–protein crosslinks (DPCs), are
common and bulky DNA lesions that interfere with DNA replication, repair, transcription and …

The fast technological development, particularly single nucleotide polymorphism array, array-
comparative genomic hybridization, and whole exome sequencing, has led to the discovery …

Proteolysis plays fundamental and regulatory roles in diverse cellular processes. The serine
protease FAM111A (FAM111 trypsin-like peptidase A) emerged recently as a protease …

Dominant missense mutations in the human serine protease FAM111A underlie perinatally
lethal gracile bone dysplasia and Kenny–Caffey syndrome, yet how FAM111A mutations …

Proteases are critical enzymes in cellular processes which regulate intricate events like
cellular proliferation, differentiation and apoptosis. This review highlights the multifaceted …

Calcium is vital for life, and extracellular calcium concentrations must constantly be
maintained within a precise concentration range. Low serum calcium (hypocalcemia) occurs …