Microtubules and microtubule-associated proteins
Microtubules act as “railways” for motor-driven intracellular transport, interact with accessory
proteins to assemble into larger structures such as the mitotic spindle, and provide an …
proteins to assemble into larger structures such as the mitotic spindle, and provide an …
Microtubule dynamics: an interplay of biochemistry and mechanics
Microtubules are dynamic polymers of αβ-tubulin that are essential for intracellular
organization, organelle trafficking and chromosome segregation. Microtubule growth and …
organization, organelle trafficking and chromosome segregation. Microtubule growth and …
The tubulin code in microtubule dynamics and information encoding
Microtubules are non-covalent mesoscale polymers central to the eukaryotic cytoskeleton.
Microtubule structure, dynamics, and mechanics are modulated by a cell's choice of tubulin …
Microtubule structure, dynamics, and mechanics are modulated by a cell's choice of tubulin …
Once and only once: mechanisms of centriole duplication and their deregulation in disease
Centrioles are conserved microtubule-based organelles that form the core of the centrosome
and act as templates for the formation of cilia and flagella. Centrioles have important roles in …
and act as templates for the formation of cilia and flagella. Centrioles have important roles in …
Microtubule-targeting agents: strategies to hijack the cytoskeleton
Microtubule-targeting agents (MTAs) such as paclitaxel and the vinca alkaloids are among
the most important medical weapons available to combat cancer. MTAs interfere with …
the most important medical weapons available to combat cancer. MTAs interfere with …
Effects of α-tubulin acetylation on microtubule structure and stability
Acetylation of K40 in α-tubulin is the sole posttranslational modification to mark the luminal
surface of microtubules. It is still controversial whether its relationship with microtubule …
surface of microtubules. It is still controversial whether its relationship with microtubule …
Microtubules acquire resistance from mechanical breakage through intralumenal acetylation
Eukaryotic cells rely on long-lived microtubules for intracellular transport and as
compression-bearing elements. We considered that long-lived microtubules are acetylated …
compression-bearing elements. We considered that long-lived microtubules are acetylated …
The microtubule cytoskeleton in cardiac mechanics and heart failure
The microtubule network of cardiac muscle cells has unique architectural and biophysical
features to accommodate the demands of the working heart. Advances in live-cell imaging …
features to accommodate the demands of the working heart. Advances in live-cell imaging …
Fungal morphogenesis, from the polarized growth of hyphae to complex reproduction and infection structures
Filamentous fungi constitute a large group of eukaryotic microorganisms that grow by
forming simple tube-like hyphae that are capable of differentiating into more-complex …
forming simple tube-like hyphae that are capable of differentiating into more-complex …
Axonal transport: cargo-specific mechanisms of motility and regulation
Axonal transport is essential for neuronal function, and many neurodevelopmental and
neurodegenerative diseases result from mutations in the axonal transport machinery …
neurodegenerative diseases result from mutations in the axonal transport machinery …