Human pluripotent stem cells have emerged as a promising in vitro model system for
studying the brain. Two-dimensional and three-dimensional cell culture paradigms have …

Although many details remain still elusive, it became increasingly evident in recent years
that mechanosensing of microenvironmental biophysical cues and subsequent …

Background While advancements in imaging techniques have led to major strides in
deciphering the human brain, successful interventions are elusive and represent some of …

The sigma-1 receptor (Sig-1R) is a chaperone receptor that primarily resides at the
mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) and acts as a …

The mechanisms underlying retinal development have not been completely elucidated.
Extracellular vesicles (EVs) are novel essential mediators of cell-to-cell communication with …

Ischemic stroke is characterized by extensive neuronal loss, glial scar formation, neural
tissue degeneration that leading to profound changes in the extracellular matrix, neuronal …

The extracellular matrix (ECM) has been identified as a critical factor affecting synaptic
function. It forms a functional scaffold that provides both the structural support and the …

In the develo** cortex, excitatory neurons migrate along the radial fibers to their final
destinations and build up synaptic connection with each other to form functional circuitry …

Synapses contain a limited number of synaptic vesicles (SVs) that are released in response
to action potentials (APs). Therefore, sustaining synaptic transmission over a wide range of …

Neuronal migration is one of the fundamental processes during brain development. Several
neurodevelopmental disorders can be traced back to dysregulated migration. Although …