Antimicrobial peptides, conventional antibiotics, and their synergistic utility for the treatment of drug‐resistant infections

Y Zhu, W Hao, X Wang, J Ouyang… - Medicinal Research …, 2022 - Wiley Online Library
Antimicrobial peptides (AMPs), also known as host defense peptides (HDPs), are important
effector immune defense molecules in multicellular organisms. AMPs exert their …

Antimicrobial peptides: Structure, mechanism, and modification

N Chen, C Jiang - European Journal of Medicinal Chemistry, 2023 - Elsevier
From the 1940s to the 1960s, the discovery of antibiotics held substantial promise for the
treatment of bacterial infection, and it was also widely used in food, agriculture, and other …

Antimicrobial peptide-based materials: Opportunities and challenges

A Rai, R Ferrão, P Palma, T Patricio… - Journal of Materials …, 2022 - pubs.rsc.org
The multifunctional properties of antimicrobial peptides (AMPs) make them attractive
candidates for the treatment of various diseases. AMPs are considered as alternatives to …

Unraveling the role of antimicrobial peptides in insects

S Stączek, M Cytryńska… - International journal of …, 2023 - mdpi.com
Antimicrobial peptides (AMPs) are short, mainly positively charged, amphipathic molecules.
AMPs are important effectors of the immune response in insects with a broad spectrum of …

[HTML][HTML] Focus: antimicrobial resistance: antimicrobial peptides therapy: an emerging alternative for treating drug-resistant bacteria

IE Mba, EI Nweze - The Yale journal of biology and medicine, 2022 - ncbi.nlm.nih.gov
Microbial resistance to antibiotics is an ancient and dynamic issue that has brought a
situation reminiscent of the pre-antibiotic era to the limelight. Currently, antibiotic resistance …

[HTML][HTML] Antimicrobial plant-derived peptides obtained by enzymatic hydrolysis and fermentation as components to improve current food systems

F Rivero-Pino, MJ Leon, MC Millan-Linares… - Trends in Food Science …, 2023 - Elsevier
Background New challenges in our society are appearing following the emergence of
antibiotic-resistant microorganisms and the concerns about the use of antibiotics …

Synergistic collaboration between AMPs and non-direct antimicrobial cationic peptides

Z Ye, L Fu, S Li, Z Chen, J Ouyang, X Shang… - Nature …, 2024 - nature.com
Non-direct antimicrobial cationic peptides (NDACPs) are components of the animal innate
immune system. But their functions and association with antimicrobial peptides (AMPs) are …

[HTML][HTML] Plant-derived antimicrobials and their crucial role in combating antimicrobial resistance

P Angelini - Antibiotics, 2024 - mdpi.com
Antibiotic resistance emerged shortly after the discovery of the first antibiotic and has
remained a critical public health issue ever since. Managing antibiotic resistance in clinical …

Mechanisms and regulation of defensins in host defense

J Fu, X Zong, M **, J Min, F Wang… - Signal Transduction and …, 2023 - nature.com
As a family of cationic host defense peptides, defensins are mainly synthesized by Paneth
cells, neutrophils, and epithelial cells, contributing to host defense. Their biological functions …

Structure–activity relationships of antibacterial peptides

MG Ciulla, F Gelain - Microbial biotechnology, 2023 - Wiley Online Library
Antimicrobial peptides play a crucial role in innate immunity, whose components are mainly
peptide‐based molecules with antibacterial properties. Indeed, the exploration of the …