Irritable bowel syndrome (IBS) is a common digestive disorder observed in clinics. Current
studies suggest that the pathogenesis of the disease is closely related to abnormal brain …

Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder defined by
ROME IV criteria as pain in the lower abdominal region, which is associated with altered …

Cerebral edema is a potentially life-threatening illness, but knowledge of its underlying
mechanisms is limited. Here we report that hypobaric hypoxia induces rat cerebral edema …

Introduction: The physiological responses on exposure to high altitude are relatively well
known, but new discoveries are still being made, and novel prevention and treatment …

Purpose The high altitude area is characterized by low pressure and hypoxia, and rapidly
entering the high altitude area will cause a series of damage to the body. Some studies have …

Exposure to extreme environments causes specific acute and chronic physiological
responses in humans. The adaptation and the physiological processes under extreme …

Hypobaric hypoxia can cause severe brain damage and mitochondrial dysfunction, and is
involved in hypoxic brain injury. However, little is currently known about the mechanisms …

We have shown that hypoxia reduces plasma insulin, which correlates with corticotropin-
releasing hormone (CRH) receptor 1 (CRHR1) in rats, but the mechanism remains unclear …

Hypoxia or intermittent hypoxia (IH) have known to alter both synthesis and secretion of
hormones. However, the effect of IH on the production of adrenal cortical steroid hormones …

We have previously reported that hypoxia activates corticotrophin-releasing hormone (CRH)
and the expression of its type-1 receptor (CRHR1) and induces disorders of the brain …