Airway hyperresponsiveness (AHR) is a key clinical feature of asthma. The presence of AHR
in people with asthma provides the substrate for bronchoconstriction in response to …

Airway hyperresponsiveness (AHR) to direct (histamine and methacholine) and indirect
(exercise, cold air, hyperventilation, AMP) challenges is a universal and defining feature of …

BACKGROUND: Airway inflammation is considered to be important in asthma but is
relatively inaccessible to study. Less invasive methods of obtaining sputum from patients …

The diverse physiological functions of histamine are mediated through distinct histamine
receptors. Mast cells are major producers of histamine, yet effects of histamine on mast cells …

Background Immune responses mediated by IgE are important in the pathogenesis of
allergic asthma. A recombinant humanized monoclonal antibody (rhuMAb-E25) forms …

Sputum cell-counts were studied in 7 non-smokers with corticosteroid-responsive chronic
cough productive of sputum and 8 smokers with a clinical diagnosis of chronic bronchitis, all …

Asthma and chronic obstructive pulmonary disease (COPD) are characterised by airflow
obstruction, airway remodelling (measurable structural change) and inflammation. The …

Airway hyper‐responsiveness (AHR) has long been considered a cardinal feature of
asthma. The development of the measurement of AHR 40 years ago initiated many …

Several short-term studies have shown that inhaled steroids can reduce airway
hyperresponsiveness in asthma. To evaluate whether prolonged treatment can bring about …

Allergic asthma, which is present in as many as 10% of individuals in industrialized nations,
is characterized by chronic airway inflammation and hyperreactivity induced by allergen …