Amphotericin B and other polyenes—Discovery, clinical use, mode of action and drug resistance
Although polyenes were the first broad spectrum antifungal drugs on the market, after 70
years they are still the gold standard to treat a variety of fungal infections. Polyenes such as …
years they are still the gold standard to treat a variety of fungal infections. Polyenes such as …
[HTML][HTML] The molecular and genetic basis of antifungal resistance in the emerging fungal pathogen Candida auris
Highlights•C. auris exhibits resistance to multiple antifungal agents and represents a public
health threat.•The molecular mechanisms of antifungal resistance observed in C. auris vary …
health threat.•The molecular mechanisms of antifungal resistance observed in C. auris vary …
Structural and mechanistic insights into fungal β-1, 3-glucan synthase FKS1
X Hu, P Yang, C Chai, J Liu, H Sun, Y Wu, M Zhang… - Nature, 2023 - nature.com
The membrane-integrated synthase FKS is involved in the biosynthesis of β-1, 3-glucan, the
core component of the fungal cell wall,. FKS is the target of widely prescribed antifungal …
core component of the fungal cell wall,. FKS is the target of widely prescribed antifungal …
Collateral sensitivity counteracts the evolution of antifungal drug resistance in Candida auris
Antifungal drug resistance represents a serious global health threat, necessitating new
treatment strategies. Here we investigated collateral sensitivity (CS), in which resistance to …
treatment strategies. Here we investigated collateral sensitivity (CS), in which resistance to …
Candidiasis: From cutaneous to systemic, new perspectives of potential targets and therapeutic strategies
Candidiasis is an infection caused by fungi from a Candida species, most commonly
Candida albicans. C. albicans is an opportunistic fungal pathogen typically residing on …
Candida albicans. C. albicans is an opportunistic fungal pathogen typically residing on …
Acquired amphotericin B resistance leads to fitness trade-offs that can be mitigated by compensatory evolution in Candida auris
Candida auris is a growing concern due to its resistance to antifungal drugs, particularly
amphotericin B (AMB), detected in 30 to 60% of clinical isolates. However, the mechanisms …
amphotericin B (AMB), detected in 30 to 60% of clinical isolates. However, the mechanisms …
Molecular mechanisms of acquired antifungal drug resistance in principal fungal pathogens and EUCAST guidance for their laboratory detection and clinical …
TR Rogers, PE Verweij, M Castanheira… - Journal of …, 2022 - academic.oup.com
The increasing incidence and changing epidemiology of invasive fungal infections continue
to present many challenges to their effective management. The repertoire of antifungal drugs …
to present many challenges to their effective management. The repertoire of antifungal drugs …
Narrow mutational signatures drive acquisition of multidrug resistance in the fungal pathogen Candida glabrata
Fungal infections are a growing medical concern, in part due to increased resistance to one
or multiple antifungal drugs. However, the evolutionary processes underpinning the …
or multiple antifungal drugs. However, the evolutionary processes underpinning the …
Molecular Epidemiological Investigation of a Nosocomial Cluster of C. auris: Evidence of Recent Emergence in Italy and Ease of Transmission during the COVID-19 …
Candida auris is an emerging MDR pathogen raising major concerns worldwide. In Italy, it
was first and only identified in July 2019 in our hospital (San Martino Hospital, Genoa) …
was first and only identified in July 2019 in our hospital (San Martino Hospital, Genoa) …
[HTML][HTML] Drug resistance and novel therapeutic approaches in invasive candidiasis
SE Murphy, T Bicanic - Frontiers in cellular and infection microbiology, 2021 - frontiersin.org
Candida species are the leading cause of invasive fungal infections worldwide and are
associated with acute mortality rates of~ 50%. Mortality rates are further augmented in the …
associated with acute mortality rates of~ 50%. Mortality rates are further augmented in the …