Recent advances in mass spectrometry based clinical proteomics: applications to cancer research
A Macklin, S Khan, T Kislinger - Clinical proteomics, 2020 - Springer
Cancer biomarkers have transformed current practices in the oncology clinic. Continued
discovery and validation are crucial for improving early diagnosis, risk stratification, and …
discovery and validation are crucial for improving early diagnosis, risk stratification, and …
Bottom-up proteomics: advancements in sample preparation
Liquid chromatography–tandem mass spectrometry (LC–MS/MS)-based proteomics is a
powerful technique for profiling proteomes of cells, tissues, and body fluids. Typical bottom …
powerful technique for profiling proteomes of cells, tissues, and body fluids. Typical bottom …
Profiling the human intestinal environment under physiological conditions
The spatiotemporal structure of the human microbiome,, proteome and metabolome, reflects
and determines regional intestinal physiology and may have implications for disease. Yet …
and determines regional intestinal physiology and may have implications for disease. Yet …
Single-pot, solid-phase-enhanced sample preparation for proteomics experiments
A critical step in proteomics analysis is the optimal extraction and processing of protein
material to ensure the highest sensitivity in downstream detection. Achieving this requires a …
material to ensure the highest sensitivity in downstream detection. Achieving this requires a …
Colonic epithelial cell diversity in health and inflammatory bowel disease
The colonic epithelium facilitates host–microorganism interactions to control mucosal
immunity, coordinate nutrient recycling and form a mucus barrier. Breakdown of the …
immunity, coordinate nutrient recycling and form a mucus barrier. Breakdown of the …
Streamlined single-cell proteomics by an integrated microfluidic chip and data-independent acquisition mass spectrometry
Single-cell proteomics can reveal cellular phenotypic heterogeneity and cell-specific
functional networks underlying biological processes. Here, we present a streamlined …
functional networks underlying biological processes. Here, we present a streamlined …
SCoPE-MS: mass spectrometry of single mammalian cells quantifies proteome heterogeneity during cell differentiation
Some exciting biological questions require quantifying thousands of proteins in single cells.
To achieve this goal, we develop Single Cell ProtEomics by Mass Spectrometry (SCoPE …
To achieve this goal, we develop Single Cell ProtEomics by Mass Spectrometry (SCoPE …
Visualizing transfer of microbial biomolecules by outer membrane vesicles in microbe‐host‐communication in vivo
M Bittel, P Reichert, I Sarfati, A Dressel… - Journal of …, 2021 - Wiley Online Library
The intestinal microbiota influences mammalian host physiology in health and disease
locally in the gut but also in organs devoid of direct contact with bacteria such as the liver …
locally in the gut but also in organs devoid of direct contact with bacteria such as the liver …
Protein aggregation capture on microparticles enables multipurpose proteomics sample preparation
Universal proteomics sample preparation is challenging because of the high heterogeneity
of biological samples. Here we describe a novel mechanism that exploits the inherent …
of biological samples. Here we describe a novel mechanism that exploits the inherent …
Single-shot 10K proteome approach: over 10,000 protein identifications by data-independent acquisition-based single-shot proteomics with ion mobility spectrometry
The evolution of mass spectrometry (MS) and analytical techniques has led to the demand
for proteome analysis with high proteome coverage in single-shot measurements. Focus has …
for proteome analysis with high proteome coverage in single-shot measurements. Focus has …